The History of Pediatric Hematopoietic Cell Transplantation Around the World
The concept of modern-day hematopoietic cell transplantation began in the 1950s with mouse studies demonstrating that the irradiated mouse would survive if the spleen was shielded and that the mouse could be protected by an infusion of spleen or marrow ce
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The History of Pediatric Hematopoietic Cell Transplantation Around the World Jean E. Sanders, Peter F. Coccia, Dietrich Niethammer, Carmemm M. Bonfim, Peter J. Shaw, and Chi-Kong Li
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Contents 1.1 1.1.1 1.1.2
Introduction ................................................ The Beginning.............................................. Early Clinical Studies ..................................
1 2 2
1.2
Pediatric HCT in the United States and Canada.................................................
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Pediatric HCT in Europe ..........................
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Pediatric HCT in South and Latin America ..................................... Transplant Activity in South and Latin American Countries .....................................
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Pediatric HCT in Australia and New Zealand .......................................
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Pediatric HCT in China.............................
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Summary.....................................................
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References .................................................................
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J.E. Sanders, MD (*) Member Emeritus Fred Hutchinson Cancer Research Center, Professor Emeritus Pediatrics, University of Washington, Seattle, Washington, USA e-mail: [email protected] P.F. Coccia, MD Ittner Professor and Vice Chair Pediatrics, University of Nebraska Medical Center, Omaha, Nebraska, USA D. Niethammer, MD Professor of Pediatrics Emeritus, Department of Pediatrics, University of Tubingen, Tubingen, Germany
Introduction
The concept of modern-day hematopoietic cell transplantation (HCT) began in the 1950s with mouse studies demonstrating that the irradiated mouse would survive if the spleen was shielded, and in other studies the mouse could be protected by an infusion of spleen or marrow cells collected prior to irradiation. Early attempts at human marrow transplant failed except in syngeneic situations, but a few successful transplants in young patients with resistant leukemia demonstrated that lethal total body irradiation (TBI) followed by infusion of compatible marrow could lead to restoration of marrow function and control of the leukemia. Since then, a reasonable estimate is that more than 88,546 children
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