The Human Yolk Sac and Yolk Sac Tumors
I am honored to have been invited to write a foreword for this book, because tumors of the yolk sac have been a preoccupation of mine since the days of my residency, now more than 3 decades ago. At that time, a 3-year-old boy died of a testicular cancer o
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The Human Yolk Sac and Yolk Sac Tumors Foreword by G. B. Pierce With 216 Figures and 25 Tables
Springer-Verlag Berlin Heidelberg New York London Paris Tokyo Hong Kong Barcelona Budapest
Dr. Francisco F. Nogales Professor of Pathology, Head of Department University Hospital, E-18012 Granada, Spain
ISBN-13: 978-3-642-77854-4 e-ISBN-13: 978-3-642-77852-0 DO I: 10.1007/ 978-3-642-77852-0
Library of Congress Cataloging-in-Publication Data. The Human yolk sac and yolk sac tumors 1 F. Nogales (ed.). p. cm. Includes bibliographical references and index. ISBN 3-540-56031-9 (alk. paper) : OM 460.00. L Yolk sac Cancer. 2. Tumors. Embryonal. 3. Yolk sac. I. Nogales, Ortiz, Francisco. [DNLM: L Gonads. 2. Mesonephroma. 3. Urogenital Neoplams. 4. Yolk Sac. WI 160 H918 1993] RC280. P7H85 1993 616.99'2 - dc20 DNLMlDLC 92-48512 This work is subject to copyright. All lights are reserved whether the whole or part of the material is concerned, specifically the rights of translation, replinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilm or in any other way, and storage in data banks. Duplication of this publication or parts thereof is permitted only under the provisions of the German Law of September 9, 1965, in its current version, and permission for use must always be obtained from Springer-Verlag. Violations are liable for prosecution under the
German Copyright Law. © Splinger-Verlag Berlin Heidelberg 1993
Softcover reprint of the hardcover 1st edition 1993
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Foreword
I am honored to have been invited to write a foreword for this book, because tumors of the yolk sac have been a preoccupation of mine since the days of my residency, now more than 3 decades ago. At that time, a 3-year-old boy died of a testicular cancer of unknown histogenesis. It was bad enough that the child died, but it bothered me even more that medical science did not know the histogenesis of the tumor that destroyed him, and I decided to study testicular cancer. For research training I sought out F. J. Dixon, who had written the Armed Forces Fascicle on testicular tumors. Dr. Dixon and I showed that embryonal carcinoma was a multipotential malignant stem cell that differentiated into the three embryonic germ layers of murine teratocarcinoma. This led to the idea that the normal counterpart of embryonal carcinoma must also be multipotent, and we focused on the preimplantation embryo for the histogenesis of the tumor. This idea was s
