The Impact of Bariatric Surgery Compared to Medical Therapy on Health-Related Quality of Life in Subjects with Obesity a

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The Impact of Bariatric Surgery Compared to Medical Therapy on Health-Related Quality of Life in Subjects with Obesity and Type 2 Diabetes Mellitus Sarah Ying Tse Tan 1 & Kwang Wei Tham 1 & Sonali Ganguly 1 & Hong Chang Tan 1 & Xiaohui Xin 2 & Henry Yuen Foong Lew 3 & Chin Hong Lim 4 & Jeremy Tan 4 & Kay Yuan Chong 5 & Phong Ching Lee 1 Received: 1 September 2020 / Revised: 2 October 2020 / Accepted: 6 October 2020 # Springer Science+Business Media, LLC, part of Springer Nature 2020

Abstract Introduction The adverse implications of obesity extend beyond physical health to include negative impact on quality of life (QoL), mood, and eating habits. While bariatric surgery provides successful weight loss and metabolic benefits, studies describe conflicting results on QoL and mood-related outcomes. Methods Patients (n = 140) with class II/III obesity and T2DM were recruited from 2015 to 2019, and stratified based on medical or surgical treatment. Questionnaires including the Hospital Anxiety and Depression Scale, Euro QoL visual analogue scale (EQVAS), and Revised 21-item Three-Factor Eating Questionnaire (TFEQ-R21) were recorded at baseline, 6 months, and 12 months after treatment. Results At baseline, the surgical group (n = 55) and medical group (n = 85) had no significant difference in questionnaire outcomes. At 6 and 12 months, EQ-VAS was higher in the surgical group (12 months surgical 82.00 ± 12.64, medical 72.81 ± 16.56, p = 0.001), with greater improvement from baseline. HADS-D scores at 12 months were lower in the surgical group (surgical 2.60 ± 2.88, medical 3.90 ± 3.58, p = 0.025). At 12 months, the surgical group also had better TFEQ-R21 scores, with higher cognitive restraint scores (surgical 19.09 ± 3.00, medical 16.69 ± 3.61, p < 0.001), and lower scores for uncontrolled eating (surgical 14.96 ± 3.87, medical 17.89 ± 5.34, p = 0.001).

Electronic supplementary material The online version of this article (https://doi.org/10.1007/s11695-020-05038-6) contains supplementary material, which is available to authorized users. * Phong Ching Lee [email protected]

Jeremy Tan [email protected]

Sarah Ying Tse Tan [email protected] Kwang Wei Tham [email protected] Sonali Ganguly [email protected]

Kay Yuan Chong [email protected] 1

Department of Endocrinology, Singapore General Hospital, Singapore, Singapore

2

Health Services Research Unit, Singapore General Hospital, Singapore, Singapore

3

Department of Psychology, Singapore General Hospital, Singapore, Singapore

4

Department of Upper Gastrointestinal and Bariatric Surgery, Singapore General Hospital, Singapore, Singapore

5

Division of Medicine, Singapore General Hospital, Singapore, Singapore

Hong Chang Tan [email protected] Xiaohui Xin [email protected] Henry Yuen Foong Lew [email protected] Chin Hong Lim [email protected]

OBES SURG

Conclusion In the treatment of patients with obesity and T2DM, bariatric surgery result