The impact of combining educational program with the improving of infrastructure to diagnose on early detection of prima
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ORIGINAL ARTICLE
The impact of combining educational program with the improving of infrastructure to diagnose on early detection of primary immunodeficiencies in children Oksana Boyarchuk 1 & Alla Volokha 2 & Tetyana Hariyan 1 & Maria Kinash 1 & Lyubov Volyanska 1 & Inna Birchenko 3 & Halyna Habor 4 & Mychaylo Korda 3
# Springer Science+Business Media, LLC, part of Springer Nature 2019
Abstract Early detection of primary immunodeficiency diseases (PID) is vital for adequate prevention and management of PID infectious complications. The objective of this study was to evaluate the impact of a model combining physician education and public awareness with the infrastructure to diagnose PID to improve its early detection in children. Three approaches were combined and the results were followed from February 2017 to February 2019 in Ternopil region, Ukraine: the education of primary care physicians and other specialists on early PID detection using workshops, trainings, and targeted publications; organization of public events and media appearances to raise PID awareness; performing immunological testing for patients with suspected PID. Among the 150 individuals that were screened, PID was diagnosed in 19 patients (12.7%). The majority of diagnosed PID cases were combined immunodeficiency with associated or syndromic features, followed by antibody deficiencies. Patients referred by the specialist doctors had the highest percentage of confirmed PID compared with those referred by primary care physicians (p = 0.0273) and risk group patients (p = 0.0447). Among warning signs in patients with PID, two or more pneumonias within 1 year occurred most often (26.3%), followed by failure of an infant to gain weight or grow normally (21.1%). Among other signs of PID, dysmorphic features and microcephaly were the most prevalent (31.6%). In conclusion, a program combining physician education and public awareness with infrastructure needed to diagnose primary immunodeficiency diseases is an effective tool for early PID diagnosis. Physician education was a more effective tool compared with rising public awareness. Keywords Primary immunodeficiencies . Diagnostic . Physician education . Public awareness
Introduction
* Oksana Boyarchuk [email protected] 1
Department of Children’s Diseases and Pediatric Surgery, I.Horbachevsky Ternopil National Medical University, 1, Maidan Voli, Ternopil 46001, Ukraine
2
Department of Children’s Infectious Diseases and Pediatric Immunology, Shupyk National Medical Academy of Postgraduate Education, 9, Dorohozhytska St, Kyiv 04112, Ukraine
3
Medical Biochemistry Department, I.Horbachevsky Ternopil National Medical University, Voli Square, 1, Ternopil 46002, Ukraine
4
Department of Functional and Laboratory Diagnostics, I.Horbachevsky Ternopil National Medical University, Voli Square, 1, Ternopil 46002, Ukraine
Primary immunodeficiency diseases (PID) is a group of more than 350 rare, chronic disorders in which a part of the body’s immune system is missing or functions improperly. Detection
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