The Impact of Tumor Biology on Cancer Treatment and Multidisciplinary Strategies

This book provides an overview of the fundamentals of tumor biology and the influence of various biologic factors, including inhomogeneity of cancer cells, microenvironment, and host factors, on the design of therapeutic strategies and the outcome of esta

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Radiation Oncology Editors: L. W. Brady, Philadelphia H.-P. Heilmann, Hamburg M. Molls, Munich C. Nieder, Bodø

M. Molls ∙ P. Vaupel ∙ C. Nieder M. S. Anscher (Eds.)

The Impact of Tumor Biology on Cancer Treatment and Multidisciplinary Strategies With Contributions by M. S. Anscher · S. T. Astner · M. J. Atkinson · M. Baumann · C. Belka · N. Cordes J. Dahm-Daphi · P. Dent · E. Dikomey · J. Drevs · I. Eke · S. Grant · P. R. Graves A.-L. Grosu · S. Hehlgans · M. Hiraoka · G. Iliakis · S. Itasaka · I. L. Jackson A. M. Kaindl · C. A. Klein · T. Klonisch · M. Krause · M. Los · M. P. Mehta · M. Gužvić M. Molls · G. Multhoff · U. Nestle · C. Nieder · J. Norum · K. Oexle · S. Panigrahi A. Pawinski · I. Rashedi · H. C. Rischke · V. Schneider · K. Schulze-Osthoff · S. Song S. Tapio · K. Valerie · P. Vaupel · Z. Vujaskovic · W. A. Weber · D. Zips Foreword by L. W. Brady, H.-P. Heilmann, M. Molls, and C. Nieder

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Michael Molls, MD

Professor, Direktor, Klinik und Poliklinik für Strahlentherapie und Radiologische Onkologie Klinikum rechts der Isar der Technischen Universität München Ismaninger Straße 22 81675 München Germany

Peter Vaupel, Dr. med., MA/Univ. Harvard

Professor of Physiology and Pathophysiology Institute of Physiology and Pathophysiology University Medical Center Duesbergweg 6 55099 Mainz Germany

Carsten Nieder, MD

Professor Department of Internal Medicine – Oncology Nordlandssykehuset HF Hospital 8092 Bodø Norway

Mitchell S. Anscher, MD, FACR, FACRO

Florence and Hyman Meyers Professor and Chair Department of Radiation Oncology Virginia Commonwealth University School of Medicine 401 College Street P. O. Box 980058 Richmond, VA 23298-0058 USA

MEDICAL RADIOLOGY ∙ Diagnostic Imaging and Radiation Oncology Series Editors: A.L. Baert ∙ L.W. Brady ∙ H.-P. Heilmann ∙ M. Knauth ∙ M. Molls ∙ C. Nieder Continuation of Handbuch der medizinischen Radiologie Encyclopedia of Medical Radiology

ISBN  978- 3-540-74385-9     e-ISBN 978-3-540-74386-6 DOI 10.1007/978-3-540-74386-6 Library of Congress Control Number: 2008928298 © 2009 Springer-Verlag Berlin Heidelberg This work is subject to copyright. All rights are reserved, wether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broad-casting, reproduction on microfilm or any other way, and storage in data banks. Duplication of this publication or parts thereof is permitted only under the provisions of the German Copyright Law of September 9, 1965, in it current version, and permission for use must always be obtained from Springer. Violations are liable to prosecution under the German Copyright Law. The use of general descriptive names, registed names, trademarks etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. Product liability: the publishers cannot guarantee the accuracy of any information about dosage and application contained in