The importance of brain banking for dementia practice: the first experience of Turkey
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SHORT COMMUNICATION
The importance of brain banking for dementia practice: the first experience of Turkey Ahmet Turan Isik . Ayca Ersen Danyeli . Derya Kaya . Pinar Soysal . Nuri Karabay . Murat Gokden
Received: 5 October 2019 / Accepted: 17 April 2020 Ó Springer Nature B.V. 2020
Abstract This study reports the results of the first brain tissue banking experience of Turkey in the Unit for Aging Brain and Dementia at Dokuz Eylul University, Department of Geriatric Medicine, Izmir. Here, we have briefly described our efforts on brain banking in our country, which consist of six brains from autopsies that had at least two years of clinical follow-up in the 2015–2017 period. The evaluation led to the diagnosis of two Alzheimer’s disease (AD) with cerebral amyloid angiopathy, one AD with dementia with Lewy bodies, one corticobasal degeneration, one multiple system atrophy, one vascular dementia. We believe that the study is of a special importance because of its potential of becoming a brain banking center in the region and because of its contributing to
the international knowledge of the neuropathological features of dementia, while characterizing the epidemiology of these diseases in the region.
A. T. Isik (&) D. Kaya Unit for Aging Brain and Dementia, Department of Geriatric Medicine, Faculty of Medicine, Dokuz Eylul University, 35340 Balcova, Izmir, Turkey e-mail: [email protected]; [email protected]
N. Karabay Department of Radiology, Faculty of Medicine, Dokuz Eylul University, Izmir, Turkey e-mail: [email protected]
D. Kaya e-mail: [email protected]
M. Gokden Division of Neuropathology, Department of Pathology, University of Arkansas for Medical Sciences, Little Rock, AR, USA e-mail: [email protected]
A. E. Danyeli Department of Pathology, Acibadem Mehmet Ali Aydinlar University, Istanbul, Turkey e-mail: [email protected]
Keywords Brain banking Neurodegenerative diseases Dementia Brain donation Brain autopsy
Introduction Diagnosis of neurodegenerative diseases such as Alzheimer’s disease (AD), Lewy bodies and dementia (DLB), vascular dementia (VaD), Parkinson’s disease (PD), frontotemporal lobar degeneration (FTLD), and
P. Soysal Department of Geriatric Medicine, Faculty of Medicine, Bezmialem Vakif University, Istanbul, Turkey e-mail: [email protected]
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Cell Tissue Bank
others are currently based on established clinical criteria, which are far from making a definitive diagnosis, because they are characterized by a complex set of neuropathological features, often with marked overlapping pathologies (Murphy and Ravina 2003). Also, it is well known that there is only a moderate relationship between some clinical diagnoses and subsequent neuropathological diagnoses (Nelson et al. 2010). It can be said that the first brain banking efforts started with anatomist collections, such as William Hunter, who archived almost fifty brain samples in the eighteenth century (Teacher 1900). Today, in many countries brain bank
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