The increase of neuropathic symptoms in diabetic patients is related with osteopenia
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ORIGINAL ARTICLE
The increase of neuropathic symptoms in diabetic patients is related with osteopenia Elif Börekci 1
&
Adem Kara 2 & Mahmut Kılıç 3 & Nermin Tanık 4 & Zeynep T. Ozan 5 & Tekin Yıldırım 5 & Yalçın Aral 6
Received: 26 June 2020 / Accepted: 16 November 2020 # Fondazione Società Italiana di Neurologia 2020
Abstract Purpose To investigate the relationship between the intensity of neuropathic pain and the severity of osteopenia in type 2 diabetic patients with painful diabetic peripheral neuropathy (painful DPN). Methods In 220 patients with type 2 diabetes included in the screening, the presence of neuropathic pain was evaluated using the Douleur Neuropathique 4 Questions (DN4) scoring system. One hundred forty-five patients with painful DPN were identified and included in the study. Socio-demographic and laboratory evaluations were made and bone mineral density (BMD) of these patients was evaluated by the dual-energy x-ray absorptiometry (DEXA) method. Results There was a significant correlation between the neuropathic pain score and the total T scores of the lumbar spine and femur in patients with painful DPN. According to the regression analysis (standard coefficients), the DN4 score (0.498); the level of vitamin D (− 0.246) and the female sex (0.236) for the lumbar spine region; age (0.387); DN4 score (0.261); and vitamin D level (− 0.155) for the femur region were independently influencing factors on the development of osteoporosis. When osteoporosis (T score ≤ − 2.5) of the lumbar spine was analyzed by binary logistic regression, the risk of osteoporosis in women was 4.4 times higher, and the risk increased with increasing DN4 score. Conclusion The increase of neuropathic symptoms in patients with DPN is an effective and important factor in the development of diabetic osteopenia. Keywords Painful diabetic peripheral neuropathy . Neuropathic pain score . Bone mineral density . Osteopenia
Introduction Diabetic peripheral neuropathy (DPN) is among the common complications of diabetes mellitus and can be seen in
* Elif Börekci [email protected] 1
Department of Internal Medicine, Celal Bayar University Faculty of Medicine, Uncubozköy, Yunus Emre, 45030 Manisa, Turkey
2
Department of Internal Medicine, Yozgat State Hospital, Yozgat, Turkey
3
Department of Public Health, Bozok University Faculty of Medicine, Yozgat, Turkey
4
Department of Neurology, Bozok University Faculty of Medicine, Yozgat, Turkey
5
Department of Internal Medicine, Bozok University Faculty of Medicine, Yozgat, Turkey
6
Department of Endocrinology, Bozok University Faculty of Medicine, Yozgat, Turkey
approximately 50% of patients with type 2 diabetes with advanced disease [1]. In 25% to 50% of patients with DPN, neuropathic pain is present [2]. Painful diabetic peripheral neuropathy (painful DPN) is a variant of distal symmetric sensorimotor polyneuropathy and the most common form of diabetic neuropathy [3]. This pain is usually localized symmetrically to the feet and may spread more proximally as the disease progr
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