The influence of maternal mental illness on vaccination uptake in children: a UK population-based cohort study
- PDF / 1,070,510 Bytes
- 11 Pages / 595.276 x 790.866 pts Page_size
- 58 Downloads / 143 Views
PSYCHIATRIC EPIDEMIOLOGY
The influence of maternal mental illness on vaccination uptake in children: a UK population‑based cohort study Cemre Su Osam1 · Matthias Pierce1 · Holly Hope1 · Darren M. Ashcroft2,3 · Kathryn M. Abel1,4 Received: 22 July 2019 / Accepted: 8 April 2020 © The Author(s) 2020
Abstract Reduced vaccination uptake is a growing and global public health concern. There is limited knowledge about the effect of maternal mental illness (MMI) on rates of childhood vaccination. This retrospective cohort study examined 479,949 motherbaby pairs born between 1993 and 2015 in the Clinical Practice Research Datalink (CPRD GOLD), a UK-based, primary health-care database. The influence of MMI on children’s vaccination status at two and five years of age was investigated using logistic regression adjusting for sex of the child, child ethnicity, delivery year, maternal age, practice level deprivation quintile and region. The vaccinations were: 5-in-1 (DTaP/IPV/Hib) and first dose MMR by the age of two; and all three doses of 5-in-1, first and second dose of MMR vaccines by the age of five. Exposure to MMI was defined using recorded clinical events for: depression, anxiety, psychosis, eating disorder, personality disorder and alcohol and substance misuse disorders. The likelihood that a child completed their recommended vaccinations by the age of two and five was significantly lower among children with MMI compared to children with mothers without mental illness [adjusted odds ratio (aOR) 0.86, 95% CI 0.84–0.88, p
Data Loading...
