The Involvement of Cell Adhesion Molecules, Tight Junctions, and Gap Junctions in Human Placentation
- PDF / 1,925,511 Bytes
- 16 Pages / 595.276 x 790.866 pts Page_size
- 62 Downloads / 210 Views
REVIEW
The Involvement of Cell Adhesion Molecules, Tight Junctions, and Gap Junctions in Human Placentation Enoch Appiah Adu-Gyamfi 1,2 & Armin Czika 2 & Philip Narteh Gorleku 3 & Amin Ullah 2 & Zulqarnain Panhwar 2 & Ling-Ling Ruan 2 & Yu-Bin Ding 1,2 & Ying-Xiong Wang 1,2 Received: 25 June 2020 / Accepted: 19 October 2020 # Society for Reproductive Investigation 2020
Abstract Placentation is a major determinant of the success of pregnancy. It is regulated by several factors such as cell adhesion molecules, tight junctions, and gap junctions. The cell adhesion molecules are integrins, cadherins, immunoglobulins, nectins, and selectins. The tight junctions are composed of claudins, occludin, and junction adhesion molecule proteins while the gap junctions are composed of connexins of varying molecular weights. During placentation, some of these molecules regulate trophoblast proliferation, trophoblast fusion, trophoblast migration, trophoblast invasion, trophoblastendothelium adhesion, glandular remodeling, and spiral artery remodeling. There is a dysregulated placental expression of some of these molecules during obstetric complications. We have, hereby, indicated the expression patterns of the subunits of each of these molecules in the various trophoblast subtypes and in the decidua, and have highlighted their involvement in physiological and pathological placentation. The available evidence points to the relevance of these molecules as distinguishing markers of the various trophoblast lineages and as potential therapeutic targets in the management of malplacentation-mediated diseases. Keywords Trophoblast . Integrin . Cadherin . Immunoglobulin . Nectin . Selectin . Claudin . Occludin . Connexin . Preeclampsia
Abbreviations PECAM1 platelet-endothelial cell adhesion molecule-1 VCAM1 vascular cell adhesion molecule-1 EMILIN1 elastin microfibril interface-located protein-1
* Enoch Appiah Adu-Gyamfi [email protected] * Yu-Bin Ding [email protected] * Ying-Xiong Wang [email protected] 1
Department of Reproductive Sciences, School of Basic Medicine, Chongqing Medical University, Chongqing 400016, People’s Republic of China
2
Joint International Research Laboratory of Reproduction & Development, Chongqing Medical University, Box 197, No. 1 Yixueyuan Rd, Chongqing 400016, People’s Republic of China
3
Department of Medical Imaging, School of Medical Sciences, University of Cape Coast, Cape Coast, Republic of Ghana
ECM Dsg2 Dsg3 PECAM1 NCAM Mel-CAM ICAM1 VCAM1 ZO CTB STB EVTs PCT DCT iEVT egEVT evEVT GC dSC dNK
extracellular matrix desmoglein-2 desmoglein-3 platelet-endothelial cell adhesion molecule-1 neural cell adhesion molecule melanoma cell adhesion molecule intercellular adhesion molecule-1 vascular cell adhesion molecule-1 zonnula occludens cytotrophoblast syncytiotrophoblast extravillous trophoblasts proximal column trophoblast distal column trophoblast intestitial extravillous trophoblast endoglandular extravillous trophoblast endovascular extravillous trophoblast giant cell decidual stromal cell de
Data Loading...
