The Local Cardiac Renin-Angiotensin Aldosterone System
The Local Cardiac Renin-Angiotensin Aldosterone System, Second Edition updates new findings on the local renin-angiotensin systems (RAS) with a focus on the local RAASs of the cardiovascular system and kidney. Edward D. Frohlich, M.D., M.A.C.P, F.A
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The Local Cardiac Renin–Angiotensin Aldosterone System
Second Edition
The Local Cardiac Renin–Angiotensin Aldosterone System Second Edition
Edward D. Frohlich · Richard N. Re Editors
The Local Cardiac Renin–Angiotensin Aldosterone System Second Edition
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Editors Edward D. Frohlich Ochsner Clinic Foundation 1514 Jefferson Highway New Orleans LA 70121 USA [email protected]
Richard N. Re Ochsner Clinic Foundation 1514 Jefferson Highway New Orleans LA 70121 USA [email protected]
ISBN 978-1-4419-0527-7 e-ISBN 978-1-4419-0528-4 DOI 10.1007/978-1-4419-0528-4 Springer New York Dordrecht Heidelberg London Library of Congress Control Number: 2009934159 © Springer Science+Business Media, LLC 2006, 2009 All rights reserved. This work may not be translated or copied in whole or in part without the written permission of the publisher (Springer Science+Business Media, LLC, 233 Spring Street, New York, NY 10013, USA), except for brief excerpts in connection with reviews or scholarly analysis. Use in connection with any form of information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed is forbidden. The use in this publication of trade names, trademarks, service marks, and similar terms, even if they are not identified as such, is not to be taken as an expression of opinion as to whether or not they are subject to proprietary rights. While the advice and information in this book are believed to be true and accurate at the date of going to press, neither the authors nor the editors nor the publisher can accept any legal responsibility for any errors or omissions that may be made. The publisher makes no warranty, express or implied, with respect to the material contained herein. Printed on acid-free paper Springer is part of Springer Science+Business Media (www.springer.com)
Preface
With great pleasure we present our Third International Workshop on The Local Cardiac Renin–Angiotensin–Aldosterone System (RAAS), held at the Ochsner Clinic Foundation in November 2008. When this meeting was first organized in 2002, we were pleased that all who were invited to participate in our first workshop attended our program; and what is most satisfying, all of these participants returned for the second and this, the third workshop. In addition, we are delighted that a number of additional workers in this growing field of investigation joined us for this third program. Over the years since our first workshop, there is little doubt as to the existence of a local RAAS in the heart. Indeed, there is substantial evidence as to the existence of other local systems in brain, vessels, adrenal, and, as presented in the current workshop, the kidneys. What is even more stimulating intellectually, through duplication of local RAAS systems a remarkable yin-yang biological balance is provided by nature. Thus, in the current third workshop considerable evidence has accumulated over the years for complicated local systems that serve to provide exquisite and
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