The Mast Cell A Multifunctional Effector Cell
This book covers the most important aspects of Mast Cell Biology. It enables the reader to immerse in the new aspects of Mast Cells biology, which are no longer seen as an immunological effector cell, but a multi-functional efector cell. One which have ro
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The Mast Cell A Multifunctional Effector Cell
The Mast Cell
Domenico Ribatti
The Mast Cell A Multifunctional Effector Cell
123
Domenico Ribatti Department of Biomedical Sciences, Neurosciences, and Sensory Organs University of Bari Bari, Italy
ISBN 978-3-030-24189-6 ISBN 978-3-030-24190-2 https://doi.org/10.1007/978-3-030-24190-2
(eBook)
© Springer Nature Switzerland AG 2019 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, expressed or implied, with respect to the material contained herein or for any errors or omissions that may have been made. The publisher remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. This Springer imprint is published by the registered company Springer Nature Switzerland AG The registered company address is: Gewerbestrasse 11, 6330 Cham, Switzerland
Contents
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1
Introduction . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . References . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
2
Mast Cell Ontogeny . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 2.1 Background . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 2.2 First Evidence of Bone Marrow Origin . . . . . . . . . . . . . 2.3 Development of Mast Cells Along the Myeloid Pathway 2.4 Stem Cell Factor . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 2.5 Integrins and Cell-Adhesion Molecules . . . . . . . . . . . . . 2.6 Chemokine Receptors and Interleukins . . . . . . . . . . . . . References . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
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3
The Staining of Mast Cells . . 3.1 Background . . . . . . . . . 3.2 Metachromasia . . . . . . . 3.3 Alcian Blue-Safranin . . 3.4 The Tyrosine Kinase Kit 3.5 Tryptase and Chymase . 3.6 Other Stainings . . . . . . References . . . . . . . . . . . . . . .
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4
Mast Cell Heterogeneity . . . . . . . . . 4.1 Background . . .
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