The Pathobiology of Pig-to-Primate Xeno.: A Historical Review
The immunologic barriers to successful xenotransplantation are related to the presence of natural anti-pig antibodies in humans and nonhuman primates that bind to antigens expressed on the transplanted pig organ (the most important of which is galactose-α
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Clinical Xenotransplantation
David K. C. Cooper • Guerard Byrne Editors
Clinical Xenotransplantation Pathways and Progress in the Transplantation of Organs and Tissues Between Species
Editors David K. C. Cooper Xenotransplantation Program University of Alabama at Birmingham Birmingham, AL USA
Guerard Byrne Department of Surgery University of Alabama at Birmingham Birmingham, AL USA
ISBN 978-3-030-49126-0 ISBN 978-3-030-49127-7 (eBook) https://doi.org/10.1007/978-3-030-49127-7 © Springer Nature Switzerland AG 2020 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors, and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, expressed or implied, with respect to the material contained herein or for any errors or omissions that may have been made. The publisher remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. This Springer imprint is published by the registered company Springer Nature Switzerland AG The registered company address is: Gewerbestrasse 11, 6330 Cham, Switzerland
Foreword
Organ transplantation was one of the great surgical advances of the second half of the twentieth century and has become one of the greatest success stories in medical history. The University of Alabama at Birmingham was early into this field when Dr. Arnold Diethelm initiated our kidney transplant program in 1968. Subsequent programs of heart, liver, pancreas, and lung transplantation followed. We have now carried out almost 15,000 organ transplants at UAB. Advances in immunosuppressive therapy have contributed to continuing improvement in the results of organ transplantation, but the field remains limited by the inadequate number of organs from deceased donors that become available each year. Xenotransplantation, using organs from genetically engineered pigs, offers a solution to the problem of donor organ availability. In collaboration with our colleagues at United Therapeutics and its subsidiary, Revivicor, UAB is playing an active role in moving the field forward. In addition to the experimental work continuing in our laboratories, we have established a “clean” pig facility that we anticipate meets US
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