The Pharmacology of Alcohol and Drugs of Abuse and Addiction

This volume is intended for clinicians, researchers, residents, and students. The range is wide and the depth considerable for all the topics covered in the treatment of this timely and relevant subject. This book may serve equally well as a general intro

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Norman S. Miller

The Pharmacology of Alcohol and Drugs of Abuse and Addiction

Springer-Verlag New York Berlin Heidelberg London Paris Tokyo Hong Kong Barcelona

Norman S. Miller, M.D. Cornell University Medical College New York Hospital-Cornell Medical Center 21 Bloomingdale Road White Plains, New York 10605

USA

With 3 illustrations. Library of Congress Cataloging-in-Publication Data Miller, Norman S. The pharmacology of alcohol and drugs of abuse and addiction / Norman S. Miller. p. cm. Includes bibliographical references. Includes index. ISBN-13: 978-1-4612-7774-3 e-ISBN-13: 978-1-4612-3044-1 DOl: 10.1007/978-1-4612-3044-1 1. Alcoholism-Physiological aspects. 2. Substance abusePhysiological aspects. 3. Alcohol-Physiological effect. 4. Psychotropic drugs - Physiological effect. I. Title. 5. Neuropsychopharmacology. [DNLM: 1. Alcohol, Ethyl-pharmacology. 2. Narcoticspharmacology. 3. Street Drugs-pharmacology. 4. Substance Abuse. 5. Substance Dependence. QV 84 M649pj RC565.M444 1990 615'.78-dc20 DNLMIDLC 90-10046 for Library of Congress Printed on acid-free paper. © 1991 Springer-Verlag New York Inc.

Softcover reprint of the hardcover 1st edition 1991 All rights reserved. This work may not be translated or copied in whole or in part without the written permission of the publisher (Springer-Verlag New York, Inc., 175 Fifth Avenue, New York, NY 10010, USA), except for brief excerpts in connection with reviews or scholarly analysis. Use in connection with any form of information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed is forbidden. The use of general descriptive names, trade names, trademarks, etc., in this publication, even if the former are not especially identified, is not to be taken as a sign that such names, as understood by the lfade Marks and Merchandise Marks Act, may accordingly be used freely by anyone. While the advice and information in this book are believed to be true and accurate at the date of going to press, neither the authors nor the editors nor the publisher can accept any legal responsibility for any errors or omissions that may be made. The publisher makes no warranty, express or implied, with respect to the material contained herein. 1}rpeset by Bytheway 'JYpesetting Services, Norwich, NY. 9 8 765 432 1

To my wife Nicole, and my daughters Mia and Natasha. Persistent partisans who generously devoted their time for this book.

Preface

This volume is intended for clinicians, researchers, residents, and students. The range is wide and the depth considerable for all the topics covered in the treatment of this timely and relevant subject. This book may serve equally well as a general introduction and a scholarly reference. Ultimately, it is designed to serve those patients suffering from abuse of and addiction to drugs and alcohol. The content and organization of the book flow from general concepts of abuse and addiction to specific details of the pharmacology of alcohol and drugs. Special chap