The Postmortem Brain in Psychiatric Research
Because of the dearth of experimental animal models of psychiatric disorders, the study of the effect of the disease state is only possible in tissue derived from patients vs. controls, especially in the target tissue of disease-related changes in the bra
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NEUROBIOLOGICAL FOUNDATION OF ABERRANT BEHAVIORS Editorial Board: MICHAEL MYSLOBODSKY Tel-Aviv University & Howard University STANLEY D. GLICK Albany Medical College MORRIS MOSCOVITCH University of Toronto DANIEL R. WEINBERGER National Institutes of Health I National Institute of Mental Health
THE POSTMORTEM BRAIN IN PSYCHIATRIC RESEARCH
edited by
Galila Agam Ben-Gurion University of the Negev Ian P Everall Institute ofPsychiatry, London R.H. Belmaker Ben-Gurion University of the Negev
SPRINGER SCIENCE+BUSINESS MEDIA, LLC
ISBN 978-1-4419-4921-9 ISBN 978-1-4757-3631-1 (eBook) DOI 10.1007/978-1-4757-3631-1 Library of Congress Cataloging-in-Publication Data A C.I.P. Catalogue record for this book is available from the Library of Congress. Copyright © 2002 by Springer Science+Business Media New York Originally published by Kluwer Academic Publishers in 2002 Softcover reprint ofthe hardcover lst edition 2002 AII rights reserved. No part of this publication may be reproduced, stored in a retrieval system or transmitted in any form or by any means, mechanical, photocopying, record ing, or otherwise, without the prior written permission of the publisher, Springer Science+Business Media, LLC
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TABLE OF CONTENTS Contributors Acknowledgements
Vll IX
Introduction EF Torrey, MB Knable
Methodology and General Findings 1. Psychiatric Brain Banks: Situation in Europe and Asia I Matsumoto, SI Niwa, R Ravid 2. Methodological and Stereological Considerations in Postmortem Psychiatric Brain Research IP Everall, PJ Harrison 3. Imaging vs. Postmortem Receptor Studies: What You See is What You Get? L Pilowsky 4. Glial Pathology and Major Psychiatric Disorders DR Cotter, CM Pariante, G Rajkowska 5. Indications of Abnormal Connectivity in Neuropsychiatric Disorders in Postmortem Studies WG Honer 6. Studies in the Human Frontal Cortex: Evidence for Changes in Neurochemical Markers in Schizophrenia and Bipolar Disorder B Dean 7. Summary of Prefrontal Molecular Abnormalities in the Stanley Foundation Neuropathology Consortium MB Knable, BM Barci, MJ Webster, EF Torrey
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21
37 49
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Schizophrenia 8. Macroanatomical Findings in Postmortem Brain Tissue from Schizophrenic Patients P Falkai
9. Microanatomical Findings in Postmortem Brain Tissue from Subjects with Schizophrenia: Disturbances in Thalamocortical and Corticocortical in Schizophrenia T Hashimoto, DA Lewis
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151
10. In Situ/Histological Approaches to NeurotransmitterSpecific Postmortem Brain Studies of Schizophrenia SE Bachus, JE Kleinman 11. Defining the Role of Specific Limbic Circuitry in the Pathophysiology of Schizophrenia and Bipolar Disorder FM Benes, S Berretta 12. Dorsolateral Prefrontal Cortical Parallel Circuit in Schizophrenia: Postmortem Abnormalities BG Bunney, WE Bunney, R Stein, SG Potkin 13. Postmortem Studies of the Hippocampal Formation in Schizophrenia AJ Dwork 14. GSK-3 and WNT Markers of
