The prevalence of metabolic disorders in various phenotypes of polycystic ovary syndrome: a community based study in Sou
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RESEARCH
Open Access
The prevalence of metabolic disorders in various phenotypes of polycystic ovary syndrome: a community based study in Southwest of Iran Fahimeh Ramezani Tehrani1, Homeira Rashidi2*, Mahnaz Bahri Khomami1, Maryam Tohidi3 and Fereidoun Azizi4
Abstract Background: Polycystic ovary syndrome (PCOS) is a common endocrinopathy, associated with metabolic abnormalities. Metabolic features of various phenotypes of this syndrome are still debatable. The aim of present study hence was to evaluate the metabolic and hormonal features of PCOS phenotypes in comparison to a group of healthy control. Methods: A total of 646 reproductive-aged women were randomly selected using the stratified, multistage probability cluster sampling method. The subjects were divided into five phenotypes: A (oligo/anovulation + hyperandrogenism + polycystic ovaries), B (oligo/anovulation + hyperandrogenism), C (hyperandrogenism + polycystic ovaries) and D (oligo/ anovulation + polycystic ovaries). Hormonal and metabolic profiles and the prevalence of metabolic syndrome among these groups were compared using ANCOVA adjusted for age and body mass index. Results: Among women with PCOS (n = 85), those of groups A and C had higher serum levels of insulin and homeostatic model assessment for insulin resistance (HOMA-IR), compared to PCOS women of group D. Serum concentrations of cholesterol, low density lipoprotein, triglycerides and glucose in group A were higher than in other phenotypes, whereas the metabolic syndrome was more prevalent among group B. Conclusions: Women who had all three components of the syndrome showed the highest level of metabolic disturbances indicating that metabolic screening of the severest phenotype of PCOS may be necessary. Keywords: PCOS, Metabolic disorders, Metabolic syndrome, Phenotype
Background Polycystic ovary syndrome (PCOS) is one of the most common, complex and heterogeneous endocrine disorders [1-4] affecting 6-10% of women of fertile age [5,6]. Although the etiology of PCOS is still unclear, genetic and environmental factors have been considered as possible contributors [1,3,7]. PCOS is complicated mainly with chronic anovulation (AnOvu), hyperandogenism (HA) and polycystic ovary manifestation (PCO) on ultrasound examination [2,3,8,9]; it is also associated with metabolic disorders such as obesity, dyslipidemia, inflammation laboratory findings, high blood pressure, insulin resistance (IR) and metabolic syndrome (MetS) [2,3,7,10], all of which lead to cardiovascular diseases [11-13]. * Correspondence: [email protected] 2 Diabetes Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran Full list of author information is available at the end of the article
IR is strongly linked to PCOS [10] and hypernandrogenism [14] and along with other hormonal irregularities has been reported to be higher among obese PCOS women than non-obese ones [1,3,15-17]; however its cause and effect relationship has not been clarified [18]. In contrast, IR is usually associated with MetS, altho
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