The right nutrition for the nutrition related diseases

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The right nutrition for the nutrition related disease Roberto Vettor 1

# Springer Science+Business Media, LLC, part of Springer Nature 2020

"Let food be your medicine and medicine be your food". Hippocrates of Kos (460–370 BC) To dedicate a special issue to the pathophysiological and clinical bases of a therapeutic strategy such as diet could seem unattractive for the current inflated proposals of colorful diets that are found in every magazine, newspaper or scientific journal, but now more than ever there is a need to bring diet therapy back to the consistency of scientific research and clinical methodology. These forward aims to trace the cultural motivations that led to this project. The true founder of ancient medicine must be considered Hippocrates of Kos (460–370 BC), an itinerant professional who practiced in various places. His Hippocratic Corpus became the most essential medical document of all time even if it was probably a collaborative effort between various physicians of ancient Greece. “Let food be your medicine and medicine be your food”. These are the famous and enlightening words of Hippocrates, who is also the author of the famous oath still used today by medical graduates; oath that commits the future doctor to act for the good of the patient, in full respect of his/her person. The father of medicine, well 400 years before the birth of Christ, had already understood the importance of nutrition in relation to our health and our psycho-physical well-being. “We are what we eat” Is it the man who makes the diet or is the diet that makes the man?Apparently it is the diet that makes man because humanity is born when it invents its diet, that is, it chooses what, how much, and how to eat. Nowadays the world is full of different national and regional cuisines and thousands of different dishes. Despite the complexity of the food and its organoleptic qualities and the mixture of the various components with various colours and the context in which the food is consumed are all elements of * Roberto Vettor [email protected] 1

Department of Medicine, Endocrine-Metabolic Unit, Padova University, Padova, Italy

great importance, for practical reasons we could analyse and reduce to the basic molecules: carbohydrates, lipids and proteins. Each class of molecule is very important for the way our body works. So, what to choose? The nutritional content of what we eat determines the composition of our cell membranes, the growth of several tissues and organs, the production of hormones and a plenty of sensing signalling and regulatory molecules. Our body are replacing billions of cells every day and the food is the source for their renewal. The diets of organisms could also affect the composition of their genes. Since organisms construct their DNA using building blocks they get from food, the composition of food could alter an organism’s DNA. Recent experimental findings revealed a previously hidden relationship between cellular metabolism and evolution, and provided new insights into how DNA sequences can be