The Role of Indirubins in Inflammation and Associated Tumorigenesis
Indirubin is the major active component of an herbal recipe ‘Dangui Luhui Wan’ (当归芦荟丸) in traditional Chinese medicine (TCM). It is widely used in China for the treatment of inflammation, cancer, and other chronic diseases and is known for good efficiency
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Abstract Indirubin is the major active component of an herbal recipe ‘Dangui Luhui Wan’ (当归芦荟丸) in traditional Chinese medicine (TCM). It is widely used in China for the treatment of inflammation, cancer, and other chronic diseases and is known for good efficiency and very low side effects. Primary studies on the mechanism of action revealed that indirubin and derivatives are potent ATP-competitive inhibitors of CDKs and GSK3ß achieving IC50 values down to the low nanomolar range. However, the clinical application of indirubins is limited by the extremely poor water solubility (
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