The Role of Magnetic Resonance Guided Focused Ultrasound for Uterine Fibroids

Uterine fibroids are the most common pelvic tumor in women. Fibroids can cause significant bleeding during menses, as well as causing pelvic pressure and pain, urinary frequency, urinary incontinence, constipation, obstetrical complications, and infertili

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Contents 1

Abstract

Uterine fibroids are the most common pelvic tumor in women. Fibroids can cause significant bleeding during menses, as well as causing pelvic pressure and pain, urinary frequency, urinary incontinence, constipation, obstetrical complications, and infertility. It has been estimated that 30 % of women with fibroids have significant symptoms. (Flynn et al. 2006) The treatment for fibroids includes: medical therapy (oral contraceptives, GRNH agonists), myomectomy (hysteroscopic, laparoscopic, and open), hysterectomy (laparoscopic/ robotic and open), and uterine artery embolization (UAE). Magnetic Resonance Guided Focused Ultrasound (MRgFUS) is being increasingly used for the treatment of uterine fibroids. Combining MR imaging to define the target and to control and monitor the ablation, and an ultrasound transducer that controls and delivers the focused ultrasound beam, MRgFUS allows a noninvasive approach to the treatment of uterine fibroids.

Introduction.......................................................................... 167

2 Physics Principles of MRgFUS .......................................... 168 2.1 Ultrasound Principles ............................................................ 168 2.2 MRI Temperature Measurement Principles.......................... 168 3

Candidates for MR Guided Focused Ultrasound............ 169

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MR Guided Focused Ultrasound Procedure.................... 170

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Complications ....................................................................... 173

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Results ................................................................................... 173

7

Where Does MRgFUS Fit into the Treatment of Fibroids? .......................................................................... 176

References...................................................................................... 177

1

A. Roberts (&) Department of Radiology, UCSD/Thornton Hospital, University of California, 9300 Campus Point Drive, San Diego, CA 92037, USA e-mail: [email protected] A. Roberts Veterans Administration Medical Center, 9300 Campus Point Drive, San Diego, CA 92037, USA

Introduction

Uterine fibroids are the most common pelvic tumor in women. Fibroids can cause significant bleeding during menses, as well as causing pelvic pressure and pain, urinary frequency, urinary incontinence, constipation, obstetrical complications, and infertility. It has been estimated that 30 % of women with fibroids have significant symptoms (Flynn et al. 2006). The treatment for fibroids includes: medical therapy (oral contraceptives, GRNH agonists), myomectomy (hysteroscopic, laparoscopic, and open), hysterectomy (laparoscopic/robotic and open), and uterine artery embolization (UAE). Magnetic Resonance Guided Focused Ultrasound (MRgFUS) is being increasingly used for the treatment of uterine fibroids. The ExAblate 2000, (InSightec, Haifa, Israel) received a CE mark in 2002 and

J. Reidy et al. (eds.), Radiological Interventions in Obstetrics and Gynaecology, Medical Radiology. Diagnostic Imaging, D