The role of simple inflammatory blood parameters in idiopathic epiretinal membrane patients
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ORIGINAL PAPER
The role of simple inflammatory blood parameters in idiopathic epiretinal membrane patients ¨ zbay . Dilek Uzlu . Hidayet Erdo¨l . Ahmet Mehmet Somuncu . Ahmet Duhan O Mehmet Kola . Bu¨s¸ ra Ko¨se
Received: 11 June 2020 / Accepted: 16 August 2020 Ó Springer Nature B.V. 2020
Abstract Aim To evaluate the neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) in idiopathic epiretinal membrane (IERM) patients, and their relations with visual acuity. Method Fifty-seven IERM and 51 control patients were included. All patients underwent comprehensive ophthalmological examination and complete blood count tests, and NLR and PLR values were calculated. Patients with IERM were compared with the control group, and associations with visual prognosis were evaluated. These ratios’ cut-off values for IERM were also calculated Results NLR values were statistically significantly higher in the IERM group than in the control group (p = 0.001). No significant difference was observed between the IERM and control groups in terms of PLR (p = 0.43). No significant correlation was determined between visual acuity and NLR or PLR (r = 0.05, p = 0.66; and r = 0.18, p = 0.16, respectively). The cut-off value for NLR was 1.91. Conclusion Patients with IERM showed significantly increased NLR compared to control subjects D. Uzlu (&) H. Erdo¨l A. M. Somuncu ¨ zbay M. Kola A. D. O Department of Ophthalmology, Medical Faculty, Karadeniz Technical University, Trabzon, Turkey e-mail: [email protected] B. Ko¨se The State Hospital of Bayburt, Bayburt, Turkey
suggesting that IERM patients may be prone to have high NLR values. Keywords Epiretinal membrane Inflammation Neutrophil-to-lymphocyte ratio Platelet-tolymphocyte ratio
Introduction Epiretinal membrane (ERM) is a vitreo-retinal interface disorder in the avascular structure caused by cell proliferation on the surface of the macula [1–3]. Causes of ERM formation are classified as primary (idiopathic) and secondary. Secondary ERMs are caused by pathologies such as retinal vascular disease (diabetic retinopathy and vascular occlusions), ocular and systemic inflammatory diseases, trauma, and previous intraocular surgery (retinal detachment surgery). Idiopathic ERM (IERM) develops in eyes with no pathology other than posterior vitreous detachment. The cellular components of IERM include glial cells, fibroblasts, and hyalocytes. These lead to IERM formation together with cytokines and growth factors in the vitreous including transforming growth factor (TGF), fibroblast growth factor (FGF), glial cell line-derived neurotrophic factor, and vascular endothelial growth factor [4, 5]. The neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) are calculated
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Int Ophthalmol
using neutrophil, platelet, and lymphocyte values measured at complete blood count (CBC) and are generally regarded as a finding of subclinical inflammation. Since they are calculated from CBC, NLR and PLR are rap
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