The role of T2-weighted images in assessing the grade of extraprostatic extension of the prostate carcinoma
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The role of T2‑weighted images in assessing the grade of extraprostatic extension of the prostate carcinoma Aslihan Onay1 · Gokhan Ertas2 · Metin Vural3 · Evrim Colak4 · Tarik Esen5 · Baris Bakir6
© Springer Science+Business Media, LLC, part of Springer Nature 2020
Abstract Purpose Extraprostatic extension (EPE) is an unfavorable prognostic factor and the grade of EPE is also shown to be correlated with the prognosis of prostate cancer. The current study assessed the value of prostate magnetic resonance imaging (MRI) in measuring the radial distance (RD) of EPE and the role of T2 WI signs in predicting the grade of EPE. Materials and methods A total of 110 patients who underwent prostate MRI before radical prostatectomy are enrolled in this retrospective study. Eighty-four patients have organ confined disease and the remaining twenty-six patients have EPE all verified by histopathology. Prostate MRI examinations were conducted with 3T MRI scanner and phased array coil with the following sequences: T2 WI, T1 WI, DCE, DWI with ADC mapping, and high b-value at b = 1500 s/mm2. The likelihood of EPE with 5-point Likert scale was assigned, several MRI features were extracted for each dominant tumor identified by using T2 WI. Tumors with Likert scales 4–5 were evaluated further to obtain MRI-based RD. The relationship between pathological and MRI-determined RD was tested. Univariate and multivariate logistic regression models were developed to detect the grade of pathological EPE. The inputs were among the 2 clinical parameters and 4 MRI features. Results There is a moderate correlation between pathological RD and MRI-determined RD (ρ = 0.45, P 6 months) between Mp-MRI and RP, short time interval (
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