The role of Th17 cells in psoriasis
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REVIEW
The role of Th17 cells in psoriasis Binbin Li 1,2 & Liangliang Huang 1 & Peng Lv 2 & Xiang Li 1 & Ge Liu 1 & Yan Chen 1 & Ziyu Wang 1 & Xiaoxian Qian 1 & Yixiao Shen 1 & Yunman Li 1 & Weirong Fang 1 Received: 2 March 2020 / Accepted: 12 August 2020 # Springer Science+Business Media, LLC, part of Springer Nature 2020
Abstract T helper 17 (Th17) cells have been involved in the pathogenesis of many autoimmune and inflammatory diseases, like psoriasis, multiple sclerosis (MS), rheumatoid arthritis (RA), and inflammatory bowel disease (IBD). However, the role of Th17 cells in psoriasis has not been clarified completely. Th17-derived proinflammatory cytokines including IL-17A, IL-17F, IL-21, IL-22, and IL-26 have a critical role in the pathogenesis of these disorders. In this review, we introduced the signaling and transcriptional regulation of Th17 cells. And then, we demonstrate the immunopathology role of Th17 cells and functions of the related cytokines in the psoriasis to get a better understanding of the inflammatory mechanisms mediated by Th17 cells in this disease. Keywords Th17 cells . Psoriasis . Differentiation . IL-17A . IL-17F . IL-21 . IL-22 . IL-26
Th17 cells Discovery of Th17 cells CD4+ T cells as the central orchestrators of immune responses can help B cell activate and produce the antibody. It is also required for T cell differentiation when chronic infection happened [1]. CD4+ T cells will differentiate into specific effector Th cells when their T cell receptor (TCR) recognized the cognate antigen on the surface of antigen-presenting cells (APCs), which is guided by the cytokine millieu and specific costimulatory. In 1986, Mosmann and Coffman earlier found two kinds of activated CD4+ T cells: Th1 and Th2 cells. The distinction between the two subsets is based on their transcription factor expression, cytokine production, and effector functions [2, 3]. Th1 cells mainly express the master transcription
* Yunman Li [email protected] * Weirong Fang [email protected] 1
State Key Laboratory of Natural Medicines, School of Basic Medical Sciences and Clinical Pharmacy, China Pharmaceutical University, Mailbox 207, Tongjiaxiang 24, Nanjing, Jiangsu 210009, People’s Republic of China
2
Chia Tai Tianqing Pharmaceutical Group Co. Ltd., No.1099, Fuying Road, Jiangning District, Nanjing, Jiangsu Province 211122, People’s Republic of China
factor T-bet and also produce cytokines like interferon gamma (IFN-γ), IL-1, and IL-2, which have proinflammatory functions. Th1 cells can protect host from intracellular infections and cancers. Th2 cells mainly express transcription factor GATA-3 and produce IL-4, IL-5, and IL-10, which are antiinflammatory in nature. Th2 can mediate host defense against helminths and also play an important role in the pathogenesis of allergic diseases [4]. The differentiation of the two subsets of CD4+ T cells are controlled by the key sequence-specific DNA-binding proteins (transcription factors, TFs), T-bet [5, 6], and GATA-3, respectively [4, 7]. In recent years, studies
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