The Scid Mouse Characterization and Potential Uses
During routine genetic screening of several immunoglobulin heavy chain congenic mouse strains in 1980, one of us (MB) was surprised to find that several mice in the C.B-17IIcr strain, which was being maintained in a specific-pathogen-free facility of the
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Editors
R. W. Compans, Birmingham/Alabama . M. Cooper, Birmingham/Alabama . H. Koprowski, Philadelphia I. McConnell, Edinburgh . F. MeIchers, Basel V. Nussenzweig, New York . M.Oldstone, La lalla/California . S. Olsnes, Oslo . H. Saedler, Cologne . P. K. Vogt, Los Angeles . H. Wagner, Vim I. Wilson, La lalla/California
The Scid Mouse Characterization and Potential Uses EMBO Workshop held at the Basel Institute for Immunology, Basel, Switzerland, February 20-22, 1989 Organized and Edited by M. J. Bosma, R. A. Phillips, and W. Schuler
With 72 Figures
Springer-Verlag Berlin Heidelberg NewYork London Paris Tokyo Hong Kong
MELVIN
J. BOSMA
Institute for Cancer Research Fox Chase Cancer Center 7701 Burholme Avenue Philadelphia, PA 19111 USA ROBERT A. PHILLIPS Division of Hematology/Oncology Hospital for Sick Children Departments oflmmunology and Genetics University of Toronto Toronto, M5G lX8 Canada WALTER SCHULER
Basel Institute for Immunology Grenzacherstra13e 487 4005 Basel Switzerland
ISBN-13:978-3-642-74976-6 e- ISBN-13: 978-3-642-74974-2 DO I: 10.1007/978-3-642-74974-2 This work is subject to copyright. All righL~ are reserved, whetherthe whole orpartof the material is concerned, specifically the rights oftranlation, reprinting, re-use of illustrations, recitation, broadcasting, reproduction on microfilms orin other ways, and storage in data banks. Duplication ofthis publication orparts thereofisonlypermitted under the provisions of the German Copyright Law ofSeptember9, 1965, in its version of June 24,1985, and a copyright fee must always be paid. Violations fall under the prosecution act of the German Copyright Law. ©Springer-Verlag Berlin Heidelberg 1989 Softcover reprint of the hardcover 1st edition
1989
Library of Congress Catalog Card Number 15-12910 The use of registered names, trademarks, etc. in this publication does not imply, even in theabsenceofaspecificstatement, thatsuch names are exempt from the relevant protective laws and regulations and therefore free for general use. Product Liability: The publishers can give no guarantee for information about drug dosage and application thereof contained in this book. In every individual case the respective user must check its accuracy by consulting other pharmaceutical literature.
2123/3020-543210
Preface
During routine genetic screening of several immunoglobulin heavy chain congenic mouse strains in 1980, one of us (MB) was surprised to find that several mice in the C.B-17IIcr strain, which was being maintained in a specific-pathogen-free facility of the Fox Chase Cancer Center (Philadelphia, PA), did not express serum immunoglobulin of the appropriate allotype. Fearing an error in the breeding of these mice, the sera of the suspect mice were screened for other allotypes. When these tests revealed a complete absence of serum immunoglobulin, it became apparent that a mutation had probably occurred in the C.B-17IIcr line. Further analysis revealed that a single breeding pair was responsible for all of the immunoglobulin negative mice and that the
