The Serum BDNF Level Offers Minimum Predictive Value for Motor Function Recovery After Stroke
- PDF / 1,255,734 Bytes
- 10 Pages / 595.276 x 790.866 pts Page_size
- 7 Downloads / 160 Views
ORIGINAL ARTICLE
The Serum BDNF Level Offers Minimum Predictive Value for Motor Function Recovery After Stroke Wenshu Luo 1,2 & Tao Liu 1,3 & Shanshan Li 1,4 & Hongmei Wen 1,5 & Fenghua Zhou 1,6 & Ross Zafonte 7 & Xun Luo 8,9 & Minghzu Xu 1 & Randie Black-Schaffer 7 & Lisa J. Wood 10 & Yulong Wang 11 & Qing Mei Wang 1,7 Received: 27 April 2018 / Revised: 3 July 2018 / Accepted: 9 July 2018 # Springer Science+Business Media, LLC, part of Springer Nature 2018
Abstract Brain-derived neurotrophic factor (BDNF) plays an important role in neuroplasticity and neurogenesis following ischemic and non-ischemic brain injury. The predictive value of BDNF for short-term outcome after stroke is controversial. The objective of this study was to investigate the relationship among serum BDNF level, fractional anisotropy (FA), and functional outcome during post-acute stroke rehabilitation. Serum BDNF levels were measured on admission to an acute inpatient rehabilitation hospital. The primary functional outcome was functional independence measure (FIM) motor subscore at discharge. The secondary outcome measures were FIM total score at discharge, FIM motor subscore on admission, length of stay in the hospital, and discharge destination. We investigated the relationship among the level of serum BDNF and FA as well as functional outcome measures. Three hundred forty-eight consecutive stroke subjects were included in the analysis. Serum BDNF levels on admission were statistically but not clinically correlated with FIM motor subscore at discharge (r = 0.173, P = 0.001) and FIM total score at discharge (r = 0.155, P = 0.004). Receiver operating characteristic (ROC) analysis of BDNF as a predictor for FIM motor subscore improvement showed low accuracy of prediction with an area under the curve (AUC) of 0.581 (P = 0.026). Serum BDNF significantly correlated with FA in the high FIM motor group (n = 10, r = 0.609, P = 0.031) but not in the low FIM motor group (n = 11, r = − 0.132, P = 0.349). The serum BDNF level alone offers minimum predictive value for recovery of motor function during post-acute rehabilitation. Our findings suggest that serum BDNF level may be correlated with FA. Wenshu Luo and Tao Liu contributed equally to this work. C o r r e s p o n d i n g a u t h o r : D r. Q i n g M e i Wa n g ([email protected]) and Co-corresponding author: Dr. Yulong Wang ([email protected]). * Yulong Wang [email protected] * Qing Mei Wang [email protected] 1
Stroke Biological Recovery Laboratory, Department of Physical Medicine and Rehabilitation, Spaulding Rehabilitation Hospital, the teaching affiliate of Harvard Medical School, Charlestown, MA 02129, USA
2
Department of Acupuncture and Moxibustion, Shenzhen Traditional Chinese Medicine Hospital, Shenzhen 518033, Guangdong, China
3
Jiangsu Provincial Key Laboratory for Interventional Medical Devices, Huaiyin Institute of Technology, Huai’an 223003, Jiangsu, China
4
Department of Microbiology, Biochemistry and Molecular Genetics, New Jersey Medical School, Rutgers, Th
Data Loading...
