The significance of myositis autoantibodies in idiopathic inflammatory myopathy concomitant with interstitial lung disea
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ORIGINAL ARTICLE
The significance of myositis autoantibodies in idiopathic inflammatory myopathy concomitant with interstitial lung disease Hung-Ling Huang 1 & Wen-Chih Lin 2 & Po-Yu Lin 3 & Meng-Yu Weng 4 & Yuan-Ting Sun 3,5 Received: 6 July 2020 / Accepted: 15 November 2020 # Fondazione Società Italiana di Neurologia 2020
Abstract Aim This study identified factors associated with interstitial lung disease (ILD) in patients with idiopathic inflammatory myopathy (IIM) based on the latest classification and recent advances in autoantibody serology. Methods We retrospectively analyzed data of 173 patients who underwent complete myositis autoantibody serology examination in a medical center in Taiwan from July 2018 to February 2020. After exclusion of patients who did not receive a final diagnosis of IIM, clinical features, serology data, concomitant diseases, treatment, presence of respiratory failure, and mortality rate of the remaining 97 patients were analyzed. Results Of IIM patients in our cohort, 47.4% had ILD. ILD was significantly associated with subtypes of IIM, older age of onset, presence of mechanic’s hand, and presence of anti-Jo-1 and anti-Ro52 antibodies. Among five IIM subtypes, overlap myositis (OM) and dermatomyositis (DM) were significantly associated with a higher prevalence rate of ILD (67.5% in OM and 53.3% in DM). Among patients with OM, the presence of anti-Jo-1 (100%), anti-PL-7 (100%), and anti-EJ antibodies (77.8%) was most significantly associated with ILD. Conclusion The latest classification of IIM, older age of onset, presence of mechanic’s hand, and presence of anti-Jo-1 and antiRo52 antibodies were significantly associated with ILD. Among five IIM subtypes, OM and DM had higher prevalence rate of ILD. Among OM patients, the presence of anti-Jo-1, anti-EJ, and anti-PL-7 antibodies was significantly associated with ILD. The study results may help physicians to timely screen and monitor pulmonary function in high-risk groups. Keywords Idiopathic inflammatory myopathy . Autoantibodies . Interstitial lung disease
Introduction Wen-Chih Lin and Po-Yu Lin contributed equally to this work. * Yuan-Ting Sun [email protected] 1
Department of Neurology, Ministry of Health and Welfare Tainan Hospital, Tainan 700, Taiwan
2
Department of Physical Medicine and Rehabilitation, Chi Mei Medical Center, Chiali branch, Tainan 722, Taiwan
3
Department of Neurology, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, 1 University Road, Tainan 701, Taiwan
4
Department of Internal Medicine, Division of Allergy, Immunology, and Rheumatology, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan 701, Taiwan
5
Department of Genomic Medicine, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan 701, Taiwan
Idiopathic inflammatory myopathy (IIM), also known as myositis, is a heterogeneous disorder characterized by muscle weakness, myalgia, elevated creatine kinas
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