The Slow Inward Current and Cardiac Arrhythmias
Since Paul Cranefield published his monograph, The Conduction of the Cardiac Impulse, in 1975, much has been learned about the role of the slow inward current in cardiac electrophysiology. Because of this expanse in know ledge, both basic and clinical, i
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DEVELOPMENTS IN
CARDIOVASCULAR MEDICINE
VOLUME 7
1. C.T. Lancee, (ed.). Echocardiology, 1979. ISBN 90-247-2209-8. 2. J. Baan, A.C. Arntzenius, E.L. Yellin, (eds). Cardiac Dynamics. 1980. ISBN 90-247-2212-8. 3. H.J.Th. Thalen, C.C. Meere, (eds). Fundamentals of Cardiac Pacing. 1979. ISBN 90-247-2245-4. 4. H.E. Kulbertus, H.J.J. Wellens, (eds). Sudden Death. 1980. ISBN 90247-2290-X 5. L.S. Dreifus, A.N. Brest, (eds). Clinical Applications of Cardiovascular Drugs. 1980. ISBN 90-247-2295-0. 6. M.P. Spencer, J.M. Reid, (eds.). Cerebrovascular Evaluation with Doppler Ultrasound. 1980. ISBN 90-247-2384-1. 8. H. Kesteloot, J.V. Joossens, (eds.). Epidemiology of Arterial Blood Pressure. 1980. ISBN 90-247-2386-8.
THE SLOW INWARD CURRENT AND CARDIAC ARRHYTHMIAS
edited by
DOUGLAS P. ZIPES, M.D. Indiana University School of Medicine Indianapolis. Indiana
JOHN C. BAILEY, M.D. Indiana University School of Medicine Indianapolis. Indiana
VICTOR ELHARRAR, Ph.D. Indiana University School of Medicine Indianapolis. Indiana
• 1980
MARTINUS NIJHOFF PUBLISHERS THE HAGUE / BOSTON / LONDON
Distributors : for the United States and Canada
Kluwer Boston, Inc. 190 Old Derby Street Hingham, MA 02043 USA for all other countries
Kluwer Academic Publishers Group Distribution Center P.O. Box 322 3300 AH Dordrecht The Netherlands
Library of Congress Cataloging in Publication Data Main entry under title: The slow inward current and cardiac arrhythmias. (Developments in cardiovascular medicine; v. 7) Includes index. l. Arrhythmia. 2. Heart conduction system. 3. Electric currents. I. Zipes, Douglas P. II. Bailey, John C. Ill. Elharrar, Victor. IV. Series. [DNLM: l. Arrhythmia. 2. Heart conduction system. WI DE997VME v. 7/ WG330 S634] RC685.A65S56 616.1'28 80-18692 ISBN-13: 978-94-009-8892-7 001: 10.1007/978-94-009-8890-3
e-ISBN-13: 978-94-009-8890-3
Copyright © 1980 by Martinus NijhofJ Publishers bv, The Hague. Softcover reprint of the hardcover 1st edition 1980 All rights reserved. No part of this publication may be reproduced, stored in a retrieval system, or transmitted in any form or by any means, mechanical, photocopying, recording, or otherwise, without the prior written permission of the publisher, Martinus NijhofJ Publishers bv, P.O. Box 566, 2501 CN The Hague, The Netherlands.
T ABLE OF CONTENTS
Preface
IX
List of contributors
Xl
I. OVERVIEW
1. Historical perspective
3
SILVIO WEIDMANN
2. The slow response and cardiac arrhythmias
11
PAUL F. CRANEFIELD
II. BASIC PROPERTIES OF THE SLOW INWARD CURRENT 3. Voltage clamp studies of the slow inward current
25
EDOUARD CORABOEUF
4. The slow inward current: non-voltage-clamp studies
97
EDW ARD CARMELIET
5. The role of cyclic AMP in regulation of the slow inward current
III
MICHAEL J. MIRRO, JOHN C. BAILEY, AUGUST M. WATANABE
6. The role of the slow inward current in impulse formation MARIO
127
V ASSALLE
7. Slow conduction in the heart
149
PAUL F. CRANEFIELD, FREDERICK A. DODGE
8. Slow inward current and contraction
173
HARRY A. FOZZARD
9. Effects of neuro
