The Th2 Type Immune Response in Health and Disease From Host Defense
The type 2 immune response that develops during infectious disease has undergone major paradigm shifts in the last several years as new cell types and pathways have been identified. It is now clear that the type 2 immune response, characterized by e
- PDF / 3,992,800 Bytes
- 183 Pages / 439.42 x 683.15 pts Page_size
- 21 Downloads / 175 Views
The Th2 Type Immune Response in Health and Disease From Host Defense and Allergy to Metabolic Homeostasis and Beyond
The Th2 Type Immune Response in Health and Disease
William C. Gause • David Artis Editors
The Th2 Type Immune Response in Health and Disease From Host Defense and Allergy to Metabolic Homeostasis and Beyond
Editors William C. Gause Rutgers New Jersey Medical School Newark, NJ, USA
David Artis, PhD Michael Kors Professor of Immunology Director, Jill Roberts Institute for Research in Inflammatory Bowel Disease Weill Cornell Medical College Cornell University Joan and Sanford I. Weill Department of Medicine Department of Microbiology and Immunology Belfer Research Building New York, NY, USA
ISBN 978-1-4939-2910-8 ISBN 978-1-4939-2911-5 DOI 10.1007/978-1-4939-2911-5
(eBook)
Library of Congress Control Number: 2015947002 Springer New York Heidelberg Dordrecht London © Springer Science+Business Media New York 2016 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. Printed on acid-free paper Springer Science+Business Media LLC New York is part of Springer Science+Business Media (www.springer.com)
Chen F et al. Neutrophils prime a long-lived effector macrophage phenotype that mediates accelerated helminth expulsion. Nat Immunol. 2014;10:938–46
Introduction
The immune response that develops after helminth infection in humans and mice exhibits a characteristic pattern of secreted proteins, called cytokines. They include interleukins (IL)-4, IL-5, IL-9, and IL-13. This signature motif helps define what is now referred to as the type 2 immune response. It is similar to the allergic immune response and also has significant similarities to the response occurring during sterile inflammation. It is, however, quite different from the type 1 response triggered by microbial pathogens that instead includes elevations in TNF, IL-12, IL-17, and IFN-γ. Understanding the events that trigger the initiation of the type 2 immune response and how the associated cell lineages i
Data Loading...
