The TIRS trial: protocol for a cluster randomized controlled trial assessing the efficacy of preventive targeted indoor
- PDF / 2,348,006 Bytes
- 19 Pages / 595.276 x 790.866 pts Page_size
- 8 Downloads / 184 Views
STUDY PROTOCOL
Open Access
The TIRS trial: protocol for a cluster randomized controlled trial assessing the efficacy of preventive targeted indoor residual spraying to reduce Aedes-borne viral illnesses in Merida, Mexico Pablo Manrique-Saide1, Natalie E. Dean2, M. Elizabeth Halloran3,4,5, Ira M. Longini2,6, Matthew H. Collins7, Lance A. Waller8, Hector Gomez-Dantes9, Audrey Lenhart10, Thomas J. Hladish6,11, Azael Che-Mendoza1, Oscar D. Kirstein12, Yamila Romer12, Fabian Correa-Morales13, Jorge Palacio-Vargas14, Rosa Mendez-Vales14, Pilar Granja Pérez14, Norma Pavia-Ruz15, Guadalupe Ayora-Talavera15 and Gonzalo M. Vazquez-Prokopec12*
Abstract Background: Current urban vector control strategies have failed to contain dengue epidemics and to prevent the global expansion of Aedes-borne viruses (ABVs: dengue, chikungunya, Zika). Part of the challenge in sustaining effective ABV control emerges from the paucity of evidence regarding the epidemiological impact of any Aedes control method. A strategy for which there is limited epidemiological evidence is targeted indoor residual spraying (TIRS). TIRS is a modification of classic malaria indoor residual spraying that accounts for Aedes aegypti resting behavior by applying residual insecticides on exposed lower sections of walls (< 1.5 m), under furniture, and on dark surfaces. (Continued on next page)
* Correspondence: [email protected] 12 Department of Environmental Sciences, Math and Science Center, Emory University, 400 Dowman Drive, 5th floor, Suite E530, Atlanta, GA 30322, USA Full list of author information is available at the end of the article © The Author(s). 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
Manrique-Saide et al. Trials
(2020) 21:839
Page 2 of 19
(Continued from previous page)
Methods/design: We are pursuing a two-arm, parallel, unblinded, cluster randomized controlled trial to quantify the overall efficacy of TIRS in reducing the burden of laboratory-confirmed ABV clinical disease (primary endpoint). The trial will be conducted in the city
Data Loading...
