The Vascular Endothelium I
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Volume 176/I Editor-in-Chief K. Starke, Freiburg i. Br. Editorial Board G.V.R. Born, London S.P. Duckles, Irvine, CA M. Eichelbaum, Stuttgart D. Ganten, Berlin F. Hofmann, München W. Rosenthal, Berlin G. Rubanyi, San Diego, CA
The Vascular Endothelium I Contributors F. Antohe, J.D. Catravas, A. Chatterjee, P.A. D’Amore, A.P. Davenport, C. Dimitropoulou, K. Egan, G.A. FitzGerald, E.A. Higgs, W.M. Kuebler, J.J. Maguire, A.B. Malik, L. McCloud, R.D. Minshall, S. Moncada, A.R. Pries, M. Simionescu, A.M. Suburo, Q.-K. Tran, H. Watanabe, G. Yetik-Anacak Editors
Salvador Moncada and Annie Higgs
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Prof. Salvador Moncada FRCP FRS The Wolfson Institute for Biomedical Research University College London Gower Street London WC1E 6BT UK E-mail: [email protected]
Ms. Annie Higgs The Wolfson Institute for Biomedical Research University College London Gower Street London WC1E 6BT UK E-mail: [email protected]
With 42 Figures and 3 Tables
ISSN 0171-2004 ISBN-10 3-540-32966-8 Springer Berlin Heidelberg New York ISBN-13 978-3-540-32966-4 Springer Berlin Heidelberg New York This work is subject to copyright. All rights reserved, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilm or in any other way, and storage in data banks. Duplication of this publication or parts thereof is permitted only under the provisions of the German Copyright Law of September 9, 1965, in its current version, and permission for use must always be obtained from Springer. Violations are liable for prosecution under the German Copyright Law. Springer is a part of Springer Science+Business Media springer.com © Springer-Verlag Berlin Heidelberg 2006 The use of general descriptive names, registered names, trademarks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. Product liability: The publishers cannot guarantee the accuracy of any information about dosage and application contained in this book. In every individual case the user must check such information by consulting the relevant literature. Editor: Simon Rallison, Heidelberg Desk Editor: Susanne Dathe, Heidelberg Cover design: design & production GmbH, Heidelberg, Germany Typesetting and production: LE-TEX Jelonek, Schmidt & Vöckler GbR, Leipzig, Germany Printed on acid-free paper 27/3100-YL - 5 4 3 2 1 0
Preface
It was with great pleasure that I accepted the invitation of Springer to edit this book. My association with the vascular endothelium covers a large part of my scientific career and, as with any good long-standing relationship, it has had moments of great excitement and periods of laborious construction. It has sometimes been difficult but has never given me cause for despondency. Indeed, in the last quarter of a century, research on the vascular endothelium has been very productive and its results have contribut
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