Thoughts on the popularity of ICSI
- PDF / 1,626,630 Bytes
- 23 Pages / 595.276 x 790.866 pts Page_size
- 64 Downloads / 178 Views
REVIEW
Thoughts on the popularity of ICSI Mounia Haddad 1 & Joshua Stewart 1 & Philip Xie 1 & Stephanie Cheung 1 & Aysha Trout 1 & Derek Keating 1 & Alessandra Parrella 1 & Sherina Lawrence 1 & Zev Rosenwaks 1 & Gianpiero D. Palermo 1 Received: 11 August 2020 / Accepted: 18 October 2020 # The Author(s) 2020
Abstract Purpose Intracytoplasmic sperm injection (ICSI) is the most widely utilized assisted reproductive technique (ART) worldwide. In this feature, we review the early assisted fertilization attempts that eventually led to the development of ICSI, and discuss its current utilization in cases of male and non-male factor infertility. Methods We researched the literature related to the development, indications, and current use of ICSI, such as sperm structural abnormalities, male genetic indications, surgically retrieved sperm, high sperm chromatin fragmentation, oocyte dysmorphism, and preimplantation genetic testing (PGT). We also describe the potential future applications of ICSI. Results This review summarizes the early micromanipulation techniques that led to the inception of ICSI. We also explore its current indications, including non-male factor infertility, where its use is more controversial. Finally, we consider the benefits of future advancements in reproductive biology that may incorporate ICSI, such as in vitro spermatogenesis, neogametogenesis, and heritable genome editing. Conclusion The versatility, consistency, and reliability of ICSI have made it the most prevalently utilized ART procedure worldwide. Keywords ICSI . IVF . Infertility . ART . History of ICSI . Application of ICSI . Development of ICSI . Versatility of ICSI . Popularity of ICSI
Introduction The topic of infertility has been explored across a wide range of fields- medicine, social science, religion, and philosophy. Infertility has led to the appearance of what is known today as assisted reproductive technology (ART), with intracytoplasmic sperm injection (ICSI) becoming the most widely used insemination method worldwide. Indeed, ICSI is used today in 66.5% [1] of fertility centers. The reliability of ICSI to achieve fertilization in cases of severe male factor infertility has led to the dramatic expansion of its use; it is now commonly utilized for low oocyte maturity, with cryopreserved oocytes, in conjunction with preimplantation genetic testing (PGT) and for patients of advanced maternal age (AMA) [1].
* Gianpiero D. Palermo [email protected] 1
The Ronald O. Perelman and Claudia Cohen Center for Reproductive Medicine, Weill Cornell Medicine, New York, NY, USA
In 2003, the Society for Assisted Reproductive Technology (SART) reported a total of 112,988 annual ART cycles in the United States, which steadily grew to 248,086 cycles by 2017 [2]. Along with this growth, patients are opting for additional ART procedures to enhance their chances of having a successful pregnancy, including oocyte cryopreservation to postpone conception, and PGT to assess the genetic profile of embryos and increase the likelihood of implantat
Data Loading...
