Tobacco Smoking and Nicotine A Neurobiological Approach

Nicotine is the major factor in the continuation of the smoking habit among humans. On December 2-4, 1985, under the sponsorship of the Tobacco and Health Research Institute in Lexington, Kentucky, leading scientists from around the world whose research e

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ADVANCES IN BEHAVIORAL BIOLOGY Editorial Board Jan Bures Irwin Kopln Bruce McEwen James McGaugh Karl Prlbram Jay RosenblaH Lawrence Welskrantz

Institute of Physiology, Prague, Czechoslovakia National Institute of Mental Health, Bethesda, Maryland Rockefeller University, New York, New York University of California, Irvine, California Stanford University School of Medicine, Stanford, California Rutgers University, Newark, New Jersey University of Oxford, Oxford, England

Recent Volumes in this Series Volume 21

COCAINE AND OTHER STIMULANTS Edited by Everett H. Ellinwood, Jr. and M. Marlyne Kilbey

Volume 22

DISCRIMINATIVE STIMULUS PROPERTIES OF DRUGS Edited by Harbans LaI

Volume 23

THE AGING BRAIN AND SENILE DEMENTIA Edited by Kalidas Nandy and Ira Sherwin

Volume 24

CHOLINERGIC MECHANISMS AND PSYCHOPHARMACOLOGY Edited by Donald J. Jenden

Volume 25

CHOLINERGIC MECHANISMS: Phylogenetic Aspects, Central and Peripheral Synapses, and Clinical Significance Edited by Giancarlo Pepeu and Herbert Ladinsky

Volume 26

CONDITIONING: Representation of Involved Neural Functions Edited by Charles D. Woody

Volume 27

THE BASAL GANGLIA: Structure and Function Edited by John S. McKenzie, Robert E. Kemm, and Lynette N. Wilcock,

Volume 28

BRAIN PLASTICITY, LEARNING, AND MEMORY Edited by B. E. Will, P. Schmitt, and J. C. Dalrymple-Alford

Volume 29

ALZHEIMER'S AND PARKINSON'S DISEASES: Strategies for Research and Development Edited by Abraham Fisher, Israel Hanin, and Chaim Lachman

Volume 30

DYNAMICS OF CHOLINERGIC FUNCTION Edited by Israel Hanin

Volume 31

TOBACCO SMOKING AND NICOTINE: A Neurobiological Approach Edited by William R. Martin, Glen R. Van Loon, Edgar T. Iwamoto, and Lay ten Davis

Volume 32

THE BASAL GANGLIA II: Structure and Function-Current Concepts Edited by Malcolm B. Carpenter and A. Jayaraman

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TOBACCO SMOKING AND NICOTINE A Neurobiological Approach Edited by

William R. Martin Glen R. Van Loon Edgar T. Iwamoto

and

Layten Davis

University of Kentucky Lexington, Kentucky

PLENUM PRESS -NEW YORK AND LONDON

Library of Congress Cataloging in Publication Data Tobacco smoking and nicotine. Proceedings of an international symposium, held Dec. 2-4, 1985, in Lexington, Ky. Includes bibliographies and index. 1. Nicotine-Physiological effect-Congresses. 2. Tobacco-Physio)ogical effect-Gongresses. 3. Neuropsychopharmacology-Congresses. I. Martin, William R. (William Robert), 1921. [DNLM: 1. Behavior-drug effects-congresses. 2. Nervous System-drug effects-congresses. 3. Nicotine-adverse effectscongresses. 4. Nicotine-pharmacodynamics-congresses. QV 137 T6278 1985) QP801.N48T63 1987 87-18513 615'.782

ISBN-13: 978-1-4612-9063-6 001: 10.1007/978-1-4613-1911-5

e-ISBN-13: 978-1-4613-1911-5

Proceedings of an international symposium on Tobacco Smoking and Health: A Neu