Trace elements in nasal polyps
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RHINOLOGY
Trace elements in nasal polyps Erdogan Okur • Asiye Gul • Metin Kilinc • M. Akif Kilic • Ilhami Yildirim • Fatma Inanc Tolun Yalcin Atli
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Received: 23 August 2012 / Accepted: 6 December 2012 / Published online: 5 January 2013 Ó Springer-Verlag Berlin Heidelberg 2013
Abstract The aim of our study is to evaluate the status of selenium and zinc in nasal polyp tissues and to investigate the possible role of trace elements and antioxidants including superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) in nasal polyps. In this study, the antioxidant enzyme and trace element levels measured in polyp tissues of 37 patients were compared with the levels measured in conchal mucosa of 27 control cases. The antioxidant enzyme and trace element levels in tissues were measured with graphite and flame spectrophotometry methods using Shimatsu UV.1601 spectrophotometer and Perkin Elmer atomic spectrometer. The mean tissue zinc and selenium levels were, respectively, 2.55 lg/g and 30.03 pg/g in patient group, 4.37 lg/g and 44.95 pg/g in control group. The mean tissue SOD and GSH-Px levels were, respectively, 4.27 and 0.69 U/mg protein in patient group, 7.09 and 0.77 U/mg protein in control group. When the measured levels in patients and control cases were compared, there were statistically
significant differences between zinc, selenium, and SOD levels (P = 0.001). There was no significant difference between GSH-Px levels (P = 0.465). In conclusion, it has been revealed that the levels of zinc, selenium, and SOD in nasal polyps were significantly lower, and it may be concluded that this may have a role in the development of nasal polyps.
E. Okur (&) Department of Otorhinolaryngology, School of Medicine, Afyon Kocatepe University, ANS Arastirma ve Uygulama Hastanesi KBB Klinigi, ˙Izmir yolu 7.km, 03200 Afyonkarahisar, Turkey e-mail: [email protected]
M. A. Kilic I. Yildirim F. I. Tolun Department of Otorhinolaryngology, School of Medicine, Kahramanmaras Sutcu Imam University, 46050 Kahramanmaras, Turkey e-mail: [email protected]
A. Gul Department of Otorhinolaryngology, Kahramanmaras State Hospital, 46050 Kahramanmaras, Turkey e-mail: [email protected] M. Kilinc Department of Biochemistry, School of Medicine, Kahramanmaras Sutcu Imam University, 46050 Kahramanmaras, Turkey e-mail: [email protected]
Keywords Nasal polyp Zinc Selenium Superoxide dismutase (SOD) Glutathione peroxidase (GSH-Px)
Introduction Nasal polyp (NP) is a chronic inflammatory disease of the paranasal sinuses. Although many theories have been put forward, a full understanding of the definite mechanisms underlying the pathogenesis of NP has yet to be achieved. Nasal polyps contain activated inflammatory cells, such as
I. Yildirim e-mail: [email protected] F. I. Tolun e-mail: [email protected] Y. Atli Department of Biochemistry, Agri Patnos State Hospital, Agri, Turkey e-mail: [email protected]
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neutrophils, lymphocytes, mast cells, and eosinophils. The most prominent factor in the developme
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