Train the brain with music (TBM): brain plasticity and cognitive benefits induced by musical training in elderly people
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Train the brain with music (TBM): brain plasticity and cognitive benefits induced by musical training in elderly people in Germany and Switzerland, a study protocol for an RCT comparing musical instrumental practice to sensitization to music Clara E. James1,2* , Eckart Altenmüller3,4, Matthias Kliegel2,5, Tillmann H.C. Krüger4,6, Dimitri Van De Ville7,8, Florian Worschech3,4, Laura Abdili1, Daniel S. Scholz3,4, Kristin Jünemann4,6, Alexandra Hering2,5, Frédéric Grouiller9, Christopher Sinke4,6 and Damien Marie1
Abstract Background: Recent data suggest that musical practice prevents age-related cognitive decline. But experimental evidence remains sparse and no concise information on the neurophysiological bases exists, although cognitive decline represents a major impediment to healthy aging. A challenge in the field of aging is developing training regimens that stimulate neuroplasticity and delay or reverse symptoms of cognitive and cerebral decline. To be successful, these regimens should be easily integrated in daily life and intrinsically motivating. This study combines for the first-time protocolled music practice in elderly with cutting-edge neuroimaging and behavioral approaches, comparing two types of musical education. Methods: We conduct a two-site Hannover-Geneva randomized intervention study in altogether 155 retired healthy elderly (64–78) years, (63 in Geneva, 92 in Hannover), offering either piano instruction (experimental group) or musical listening awareness (control group). Over 12 months all participants receive weekly training for 1 hour, and exercise at home for ~ 30 min daily. Both groups study different music styles. Participants are tested at 4 time points (0, 6, and 12 months & post-training (18 months)) on cognitive and perceptual-motor aptitudes as well as via wide-ranging functional and structural neuroimaging and blood sampling. (Continued on next page)
* Correspondence: [email protected] Table 1 (p. 6) depicts the WHO (World Health Organization) Trial Registration Set, to serve as a brief structured summary of the study. 1 Geneva School of Health Sciences, Geneva Musical Minds Lab (GEMMI Lab), University of Applied Sciences and Arts Western Switzerland HES-SO, Avenue de Champel 47, 1206 Geneva, Switzerland 2 Faculty of Psychology and Educational Sciences, University of Geneva, Boulevard du Pont-d’Arve 40, 1205 Geneva, Switzerland Full list of author information is available at the end of the article © The Author(s). 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If mater
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