Translation of Biomarkers into Clinical Practice
The practice of precision medicine requires reliable and informative biomarkers to guide clinical management decisions. Tests based on biomarkers may be used for a variety of purposes, including to inform prognosis, select therapy, and monitor for disease
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ecular Pathology of Breast Cancer
Molecular Pathology of Breast Cancer
Sunil Badve Yesim Gökmen-Polar •
Editors
Molecular Pathology of Breast Cancer
123
Editors Sunil Badve Department of Pathology and Laboratory Medicine Indiana University School of Medicine Indianapolis, IN USA
ISBN 978-3-319-41759-2 DOI 10.1007/978-3-319-41761-5
Yesim Gökmen-Polar Department of Pathology and Laboratory Medicine Indiana University School of Medicine Indianapolis, IN USA
ISBN 978-3-319-41761-5
(eBook)
Library of Congress Control Number: 2016950893 © Springer International Publishing Switzerland 2016 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. Printed on acid-free paper This Springer imprint is published by Springer Nature The registered company is Springer International Publishing AG The registered company address is: Gewerbestrasse 11, 6330 Cham, Switzerland
Preface
Data is not information, information is not knowledge, knowledge is not understanding, understanding is not wisdom —Clifford Stoll Lawrence Berkeley National Laboratory, USA
The last few years has seen the deluge of data regarding the alterations in breast cancers. Recent advances in technology also permit analysis of single cells for these alterations. However, clinicians and scientists faced with an onslaught of this data from the scientific and lay press are finding it difficult to distinguish data from information. The major question that arises is—how does it affect the lives of my patients? My research? Molecular Pathology of Breast Cancer seeks to provide an overview of the recent advances in breast cancer and bring together the techniques, data, and knowledge to provide some understanding and wisdom. We believe that this work will represent a new and important resource for clinicians and scientists, by serving as a “ready reckoner.” The chapters, written by experts in the field, provide valuable information to those already involved in and familiar with the complexities of breast cancer. In order to introduc
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