Traumatic brain injury with concomitant injury to the spleen: characteristics and mortality of a high-risk trauma cohort
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ORIGINAL ARTICLE
Traumatic brain injury with concomitant injury to the spleen: characteristics and mortality of a high‑risk trauma cohort from the TraumaRegister DGU® Marius Marc‑Daniel Mader1,2 · Rolf Lefering3 · Manfred Westphal1 · Marc Maegele4,3 · Patrick Czorlich1 Received: 18 August 2020 / Accepted: 31 October 2020 © The Author(s) 2020
Abstract Purpose Based on the hypothesis that systemic inflammation contributes to secondary injury after initial traumatic brain injury (TBI), this study aims to describe the effect of splenectomy on mortality in trauma patients with TBI and splenic injury. Methods A retrospective cohort analysis of patients prospectively registered into the TraumaRegister D GU® (TR-DGU) with TBI ( AISHead ≥ 3) combined with injury to the spleen (AISSpleen ≥ 1) was conducted. Multivariable logistic regression modeling was performed to adjust for confounding factors and to assess the independent effect of splenectomy on in-hospital mortality. Results The cohort consisted of 1114 patients out of which 328 (29.4%) had undergone early splenectomy. Patients with splenectomy demonstrated a higher Injury Severity Score (median: 34 vs. 44, p
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