Treatment of one case of cerebral palsy combined with posterior visual pathway injury using autologous bone marrow mesen
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RESEARCH
Open Access
Treatment of one case of cerebral palsy combined with posterior visual pathway injury using autologous bone marrow mesenchymal stem cells Min Li1, Aixue Yu1, Fangfang Zhang1, GuangHui Dai1, Hongbin Cheng1, Xiaodong Wang1 and Yihua An1,2*
Abstract Background: Cerebral palsy is currently one of the major diseases that cause severe paralysis of the nervous system in children; approximately 9–30% of cerebral palsy patients are also visually impaired, for which no effective treatment is available. Bone marrow mesenchymal stem cells (BMSCs) have very strong self-renewal, proliferation, and pluripotent differentiation potentials. Therefore, autologous BMSC transplantation has become a novel method for treating cerebral palsy. Methods: An 11-year-old boy had a clear history of dystocia and asphyxia after birth; at the age of 6 months, the family members observed that his gaze roamed and noted that he displayed a lack of attention. A brain MRI examination at the age of 7 years showed that the child had cerebral palsy with visual impairment (i.e., posterior visual pathway injury). The patient was hospitalized for 20 days and was given four infusions of intravenous autologous BMSCs. Before transplantation and 1, 6, and 12 months after transplantation, a visual evoked potential test, an electrocardiogram, routine blood tests, and liver and kidney function tests were performed. Results: The patient did not have any adverse reactions during hospitalization or postoperative follow-up. After discharge, the patient could walk more smoothly than he could before transplantation; furthermore, his vision significantly improved 6 months after transplantation, which was also supported by the electrophysiological examinations. Conclusions: The clinical application of BMSCs is effective for improving vision in a patient with cerebral palsy combined with visual impairment.
Background This case study represents a typical case of cerebral palsy combined with visual impairment. With medical advances, the active treatment of preterm infants, children with dystocia, and children with encephalitis or hypoxic-ischemic encephalopathy results in significant increases in the survival rates of these patients; however, compared to normal infants, these patients have significantly increased incidences of periventricular white matter demyelination. Many regions of the brain play
important roles in the generation of vision, such as the cerebral cortex, the white matter, and the basal ganglia [1-3]. During the perinatal period, most cerebral palsy patients have a history of intrauterine hypoxia, preterm birth, dystocia, asphyxia after birth, kernicterus, or other complications. These factors can all result in impaired function of the visual areas of the brain, which currently has no effective treatment.
Methods * Correspondence: [email protected] 1 Department of stem cell transplantation, General Hospital of Chinese People’s Armed Police Forces, Beijing 100039, China 2 Beijing Neurosurgical Institute, Beijing Tiantan Hospital, Capi
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