Treatment Planning
Treatment planning for neutron capture therapy (NCT) involves computation and analysis of the radiation dose distribution in a patient for determination of the neutron beam orientations and radiation fluence (monitor units) to enable delivery of an optimi
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W.S. Kiger III and Hiroaki Kumada
Contents 16.1 Introduction ................................................................................................................
288
16.2 Computational Aspects of Treatment Planning ...................................................... 16.2.1 Patient Geometric Modeling Approaches ...................................................... 16.2.2 Neutron Beam Source Definition ................................................................... 16.2.3 Dose Calculations .......................................................................................... 16.2.4 Planning System Quality Assurance and Verification.................................... 16.2.5 Planning System Calibration and Validation ................................................. 16.2.6 Treatment Planning Systems ..........................................................................
289 289 294 296 302 303 307
16.3 Clinical Aspects: The Treatment Planning Process ................................................ 16.3.1 Patient Data Acquisition ................................................................................ 16.3.2 Image Processing ........................................................................................... 16.3.3 Target Volume Definition ............................................................................... 16.3.4 Model Construction ....................................................................................... 16.3.5 Beam Selection .............................................................................................. 16.3.6 Plan Evaluation and Optimization ................................................................. 16.3.7 Dose Prescription ........................................................................................... 16.3.8 Treatment Plan Quality Assurance.................................................................
307 308 308 309 309 310 312 314 315
16.4 Treatment Delivery..................................................................................................... 16.4.1 Patient Positioning and Immobilization ......................................................... 16.4.2 Pharmacokinetic Modeling for 10B Prediction ...............................................
315 315 317
16.5 Retrospective Analysis and Dose Reporting ............................................................
319
16.6 Future Directions........................................................................................................
320
References ..............................................................................................................................
322
W.S. Kiger III (*) Department of Radiation Oncology, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Avenue, Shapiro 505, Boston, MA 02215, USA e-mail: [email protected] H. Kumada Faculty of Medicine, Proton Medical Research Center, University of Tsukuba, 2-1-1 Amakubo, Tsukuba, Ibaraki 305-8576, Japan e-mail: kumad
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