Triblock Copolymer Micelle-Crosslinked Hydrogels
This chapter reviews the preparation, structures, properties, and applications of tough and responsive hydrogels crosslinked by triblock copolymer micelles. An amphiphilic triblock copolymer, Pluronic F127, is functionalized with reactive groups. The func
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Triblock Copolymer Micelle-Crosslinked Hydrogels Jun Fu
Contents 1 Introduction 2 Triblock Copolymer Micelle-Crosslinked Hydrogels 2.1 Mechanical Properties 2.2 Effect of Solvent on Structures and Properties 3 Multi-responsive Hydrogels 4 Macroscopically Assembled Devices 5 Supramolecular Micelle-Crosslinked Hydrogels 6 Conclusions References
Abstract This chapter reviews the preparation, structures, properties, and applications of tough and responsive hydrogels crosslinked by triblock copolymer micelles. An amphiphilic triblock copolymer, Pluronic F127, is functionalized with reactive groups. The functional F127 chains form polyfunctional micelles in aqueous solution, which are used for reaction with hydrophilic monomers or polymer chains to form hydrophobically crosslinked network. Free radical polymerization, host-guest interaction, and dynamic bonds have been utilized to connect the polymer chains with the reactive micelle coronae. The obtained polymer hydrogels show outstanding strength and toughness, with the micelles serving as energy dissipation centers. The structural evolution and energy dissipation mechanisms have been investigated in detail. By incorporating functional monomers into the network, a series of functional hydrogels responsive to pH, salt, electric field, and temperature have been developed. The hydrogels have been utilized as building blocks to fabricate soft actuators, shape-morphing devices, and biomaterials for tissue repair.
J. Fu (*) School of Materials Science and Engineering, Sun Yat-sen University, Guangzhou, China e-mail: [email protected]
J. Fu
Keywords Hydrophobic association · Micelles · Pluronic F127 · Responsiveness · Shape morphing · Soft actuator · Tough hydrogels · Triblock copolymer
Abbreviations 2D β-CD AAm AMPS AZO CC gels DC DLS DMAEA-Q DMAEMA DMSO F127 F127DA HAAD HEMA IS NaMAA PAAm PAMPS PDMAEA-Q PEG PNIPAM SAXS SEM TEM
Two dimension β-Cyclodextrin Acrylamide 2-Acrylamide-2-methylpropanesulfonic acid 4-(Phenylazo)benzoic acid Chemically crosslinked hydrogels Direct current Dynamic light scattering (2-(Acryloyloxy)ethyl)trimethylammonium chloride 2-(Dimethylamino)ethyl methacrylate Dimethyl sulfoxide Pluronic F127, poly(ethylene oxide-propylene oxide-ethylene oxide) Pluronic F127 diacrylate Hydrazine-modified hyaluronic acid 2-Hydroxyethyl methacrylate Ionic strength Sodium methacrylate Polyacrylamide Poly(2-acrylamide-2-methylpropanesulfonic acid) Poly((2-(acryloyloxy)ethyl)trimethylammonium chloride) Poly(ethylene glycol) Poly(N-isopropylacrylamide) Small-angle X-ray scattering Scanning electron microscopy Transmission electron microscopy
1 Introduction Among the non-covalent interactions used to crosslink hydrophilic polymer chains into networks, hydrophobic association has been very widely and successfully used as the mechanism for crosslinking and energy dissipation [1–3]. Okay et al. used micelles of small molecular surfactants to create a nanometer-sized spot for the local polymerization and association of hydrophobic monomers to form hydrophobic cro
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