Tropical Diseases From Molecule to Bedside

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ADVANCES IN EXPERIMENTAL MEDICINE AND BIOLOGY Editorial Board: N A T H A N B A C K , State University of New York at Buffalo I R U N R. C O H E N , The Weizmann Institute of Science D A V I D K R I T C H E V S K Y , Wistar Institute A B E L L A J T H A , N. S. Kline Institute for Psychiatric Research R O D O L F O P A O L E T T I , University of Milan

Recent Volumes in this Series Volume 523 ADVANCES IN MODELLING AND CLINICAL APPLICATION OF INTRAVENOUS ANAESTHESIA Edited by Jaap Vuyk and Stefan Schraag. Volume 524 DIPEPTIDYL AMINOPEPTIDASES IN HEALTH AND DISEASE Edited by Martin Hildebrandt, Burghard F. Klapp, Torsten Hoffmann, and Hans-Ulrich Demuth Volume 525 ADVANCES IN PROSTAGLANDIN, LEUKOTRIENE, AND OTHER BIOACTIVE LIPID RESEARCH: Basic Science and Clinical Applications Edited by Zeliha Yazici, Giancarlo Folco, Jeffrey M. Drazen, Santosh Nigam, and Takao Shimizu Volume 526 TAURINE 5: Beginning the 21st Century Edited by John B. Lombardini, Stephen W. Schaffer, and Junichi Azuma Volume 527 DEVELOPMENTS IN TRYPTOPHAN AND SEROTONIN METABOLISM Edited by Graziella Allegri, Carlo V. L. Costa, Eugenio Ragazzi, Hans Steinhart, and Luigi Varesio Volume 528 AD A M ANTI ADES-BEH£ET S DISEASE Edited by Christos C. Zouboulis Volume 529 THE GENUS YERSINIA: Entering the Functional Genomic Era Edited by Mikael Skurnik, Jose Antonio Bengoechea, and Kaisa Granfors Volume 530 OXYGEN TRANSPORT TO TISSUE XXIV Edited by Jeffrey F. Dunn and Harold M . Swartz Volume 531 TROPICAL DISEASES: From Molecule to Bedside Edited by Sangkot Marzuki, Jan Verhoef, and Harm Snippe

A Continuation Order Plan is available for this series. A continuation order will bring delivery of each new volume immediately upon publication. Volumes are billed only upon actual shipment. For further information please contact the publisher.

TROPICAL DISEASES From Molecule to Bedside Edited by

Sangkot Marzuki Eijkman Institute for Molecular Jakarta, Indonesia

Biology

Jan Verhoef and Harm Snippe Eijkman-Winkler Centre University Medical Centre Utrecht Utrecht, The Netherlands

Springer Science+Business Media, LLC

Proceedings of the Second International Eijkman Symposium on Tropical Diseases: From Molecule to Bedside: In the Footsteps of Christiaan Eijkman, held September 2-6, 2001, in Bogor, Indonesia ISSN 0065-2598 ISBN 978-1-4613-4905-1 ISBN 978-1-4615-0059-9 (eBook) DOI 10.1007/978-1-4615-0059-9 ©2003 Springer Science+Business Media New York Originally published by Kluwer Academic/Plenum Publishers, New York i n 2003 Softcover reprint of the hardcover 1 st edition 2003 http ://www. wkap. nl/ 10

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A C L P . record for this book is available from the Library of Congress A l l rights reserved No part of this book may be reproduced, stored in a retrieval system, or transmitted in any form or by any means, electronic, mechanical, photocopying, microfilming, recording, or otherwise, without written permission from the Publisher, with the exception of any material supplied specifically for the purpose of being entered and executed on a