Tumor Microenvironment The Main Driver of Metabolic Adaptation

This book will allow readers to discover the crucial role of tumor microenvironment (TME) in the selection of cancer cells that are more prone to carry on cancer initiation and progression. The metabolic remodeling, as the basis of life overall, allows th

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Jacinta Serpa  Editor

Tumor Microenvironment The Main Driver of Metabolic Adaptation

Advances in Experimental Medicine and Biology Volume 1219 Editorial Board: WIM E. CRUSIO, Institut de Neurosciences Cognitives et Intégratives d’Aquitaine, CNRS and University of Bordeaux UMR 5287, Pessac Cedex, France JOHN D. LAMBRIS, University of Pennsylvania, Philadelphia, PA, USA HEINFRIED H. RADEKE, Institute of Pharmacology & Toxicology, Clinic of the Goethe University Frankfurt Main, Frankfurt am Main, Germany NIMA REZAEI, Research Center for Immunodeficiencies, Children’s Medical Center, Tehran University of Medical Sciences, Tehran, Iran

More information about this series at http://www.springer.com/series/5584

Jacinta Serpa Editor

Tumor Microenvironment The Main Driver of Metabolic Adaptation

Editor Jacinta Serpa CEDOC, Chronic Diseases Research Centre, NOVA Medical School | Faculdade de Ciências Médicas Universidade NOVA de Lisboa Lisbon, Portugal Instituto Português de Oncologia de Lisboa Francisco Gentil (IPOLFG) Lisbon, Portugal

ISSN 0065-2598     ISSN 2214-8019 (electronic) Advances in Experimental Medicine and Biology ISBN 978-3-030-34024-7    ISBN 978-3-030-34025-4 (eBook) https://doi.org/10.1007/978-3-030-34025-4 © Springer Nature Switzerland AG 2020 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors, and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, expressed or implied, with respect to the material contained herein or for any errors or omissions that may have been made. The publisher remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. This Springer imprint is published by the registered company Springer Nature Switzerland AG. The registered company address is: Gewerbestrasse 11, 6330 Cham, Switzerland

Contents

1 Metabolic Remodeling as a Way of Adapting to Tumor Microenvironment (TME), a Job of Several Holders ����������������    1 Jacinta Serpa 2 Tumor Microenvironment – Selective Pressures Boosting Cancer Progression��������������������������������������������������������   35 Sofia C. Nunes 3 Lactate and Lactate Transporters as Key Players in the Maintenance of the Warb