Twenty Years of G-CSF Clinical and Nonclinical Discoveries
Granulocyte colony-stimulating factor (G-CSF or GCSF) is a secreted glycoprotein that stimulates the proliferation and differentiation of granulocyte precursor cells, and induces mobilization of peripheral blood progenitor cells from the bone marrow. Deve
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Series Editors Michael J. Parnham, University Hospital for Infectious Diseases, Zagreb, Croatia, Jacques Bruinvels, Bilthoven, The Netherlands
Advisory Board J.C. Buckingham, Imperial College School of Medicine, London, UK R.J. Flower, The William Harvey Research Institute, London, UK A.G. Herman, Universiteit Antwerpen, Antwerp, Belgium P. Skolnick, National Institute on Drug Abuse, Bethesda, MD, USA
For further volumes: http://www.springer.com/series/4991
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Graham Molineux MaryAnn Foote
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Tara Arvedson
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Editors
Twenty Years of G-CSF Clinical and Nonclinical Discoveries
Volume Editors Dr. Graham Molineux Amgen Inc. Thousand Oaks, CA 91320 USA [email protected]
Dr. MaryAnn Foote MA Foote Associates Westlake Village, CA 91362 USA [email protected]
Dr. Tara Arvedson Amgen Inc. Thousand Oaks, CA 91320 USA [email protected]
Series Editors Prof. Michael J. Parnham, Ph.D. Visiting Scientist Research & Clinical Immunology Unit University Hospital for Infectious Diseases “Dr. Fran Mihaljevic´” Mirogojska 8 HR-10000 Zagreb Croatia Prof. Dr. Jacques Bruinvels Sweelincklaan 75 NL-3723 JC Bilthoven The Netherlands
ISBN 978-3-0348-0217-8 e-ISBN 978-3-0348-0218-5 DOI 10.1007/978-3-0348-0218-5 # Springer Basel AG 2012 This work is subject to copyright. All rights are reserved, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, re-use of illustrations, recitation, broadcasting, reproduction on microfilms or in other ways, and storage in data banks. For any kind of use, permission of the copyright owner must be obtained. The use of general descriptive names, registered names, trademarks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. Product liability: The publishers cannot guarantee the accuracy of any information about dosage and application contained in this book. In every individual case the user must check such information by consulting the relevant literature. Printed on acid-free paper Springer Basel AG is part of Springer Science þ Business Media (www.springer.com)
Preface
On April 25, 1953, 58 years ago, JD Watson and FHC Crick published their article entitled “A Structure for Deoxyribose Nucleic Acid” in the journal Nature. This article has been cited for its brevity, only 1 page and 1 diagram. The impact of this article cannot be fully measured, but it is safe to suggest that recombinant DNA biopharmaceuticals, such as recombinant human granulocyte colony-stimulating factor (rmet-HuG-CSF), would not be available today without the basic knowledge of DNA structure. A quick search of PubMed suggests that no articles had been published on the topic of rmet-HuG-CSF or even G-CSF as of 1953. Forward to April 2011 and a quick search of PubMed cites 31,965 articles tagged to “G-CSF,” 1,753 tagged to “filgrastim,” 350 tagged to “pegfilgrastim,” 295 tagged to “lenograstim,” and 13 tagged to “biosimilar filg
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