Two year effects of food allergen immunotherapy on quality of life in caregivers of children with food allergies
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RESEARCH
ALLERGY, ASTHMA & CLINICAL IMMUNOLOGY
Open Access
Two year effects of food allergen immunotherapy on quality of life in caregivers of children with food allergies Stefania Arasi1,2, Iris M Otani1,2, Erik Klingbeil1,2, Philippe Bégin1,2, Clare Kearney1,2, Tina LR Dominguez1,2, Whitney M Block1,2, Geraldine O’Riordan1,2 and Kari C Nadeau1,2*
Abstract Background: Food allergy (FA) can have serious psychosocial and economic repercussions on food-allergic children and their caregivers and be associated with negative effects on their quality of life. Food allergen immunotherapy (IT) is a promising experimental therapy but can be linked to anxiety. This study investigated the effects of IT on FA-specific health-related quality of life (HRQL) over a 24 month-follow-up in caregivers of children with single and multiple food allergies. We hypothesized that characteristics such as age, asthma at baseline and respiratory allergic reactions during therapy were key characteristics that influenced HRQL scores. Methods: A validated Food Allergy Quality of Life – Parental Burden Questionnaire (FAQL-PB) was used to assess HRQL. It was randomly distributed to and filled out by caregivers of 57 food-allergic children enrolled in clinical trials of IT. The same parent answered the FABQL-PB questionnaire at baseline and for 6-month, 12- month, 18- month, and 24-month time points on IT. Results: Caregiver HRQL improved significantly (change < - 0.5, p
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