Uncontrolled hypertension associates with subclinical cerebrovascular health globally: a multimodal imaging study
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MAGNETIC RESONANCE
Uncontrolled hypertension associates with subclinical cerebrovascular health globally: a multimodal imaging study Wenjin Liu 1 & Xiaoqin Huang 2 & Xuebing Liu 3 & Dakota Ortega 1 & Li Chen 4 & Zhensen Chen 1 & Jie Sun 1 & Lulu Wang 2 & Thomas S. Hatsukami 5 & Chun Yuan 1 & Haige Li 3 & Junwei Yang 2 Received: 25 March 2020 / Revised: 16 July 2020 / Accepted: 21 August 2020 # European Society of Radiology 2020
Abstract Objectives The study aimed to analyze the association between hypertension control and subclinical cerebrovascular health using a comprehensive multimodal imaging approach. Methods The study included 200 hypertensive older males without previous cardiovascular diseases. Clinic blood pressure (BP) was measured using a standard approach. Cerebrovascular health was evaluated using magnetic resonance imaging in the following four aspects: Intracranial atherosclerosis as determined by vessel wall imaging; Vascular rarefaction (defined as less discernible vessels on angiography) was evaluated using a custom-developed technique. Cerebral blood flow (CBF) and white matter hyperintensity (WMH) were assessed using arterial spin-labeling imaging and fluid-attenuated inversion recovery imaging, respectively. Results A total of 189 subjects had MRI scans. The mean age was 64.9 (± 7.2) years. For intracranial atherosclerosis, there was a significant association between uncontrolled hypertension and presence of intracranial plaque. When systolic and diastolic BP were analyzed separately, the association remained significant for both. For vascular rarefaction, uncontrolled hypertension was associated with less discernible vessel branches or shorter vessel length on angiography. Further analysis revealed that this is due to uncontrolled diastolic BP, but not uncontrolled systolic BP. There was an association between uncontrolled hypertension and reduced CBF, which was also mainly driven by uncontrolled diastolic BP. We also found that uncontrolled diastolic BP, but not uncontrolled systolic BP, was associated with increased WMH volume. Conclusions Uncontrolled hypertension was associated with subclinical cerebrovascular injury globally, with both small and medium-to-large arteries being affected. Key Points • In this study, we leveraged the advantage of a series of cutting-edge MR imaging and analysis techniques and found uncontrolled hypertension is associated with subclinical globally compromised cerebrovascular health. • The detrimental consequences of uncontrolled BP affect not only the small vessels but also the medium-to-large arteries, and uncontrolled systolic and diastolic BP are both independently associated with certain types of cerebrovascular injury. • Our data suggest that cerebrovascular health is impaired globally in uncontrolled hypertension before the onset of stroke.
Electronic supplementary material The online version of this article (https://doi.org/10.1007/s00330-020-07218-5) contains supplementary material, which is available to authorized users. * Haige Li [email protected]
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