Understanding the dynamics of asthma symptoms between childhood and adolescence using latent transition analysis
- PDF / 800,377 Bytes
- 11 Pages / 595.276 x 790.866 pts Page_size
- 5 Downloads / 179 Views
ORIGINAL ARTICLE
Understanding the dynamics of asthma symptoms between childhood and adolescence using latent transition analysis Ana Clara P. Campos1 • Leila Denise A. F. Amorim2,3
•
Agostino Strina3 • Maurı´cio L. Barreto1,3
Received: 2 February 2020 / Revised: 8 July 2020 / Accepted: 12 July 2020 / Published online: 31 July 2020 Swiss School of Public Health (SSPH+) 2020
Abstract Objectives Asthma patterns in childhood are important predictors of unwanted outcomes in adolescence. We aimed to define asthma phenotypes in childhood and adolescence and evaluate the transitions between these phenotypes and factors potentially associated with the transitions. Methods Baseline (1445 children), first round (1363 children/early adolescents) and second round (1206 adolescents) data from the SCAALA Project in Salvador, Brazil, were used. Phenotypes were defined by latent class analysis at three time points. Transitions between phenotypes were described and the effects of factors associated with transition probabilities estimated using latent transition analysis. Results The ‘‘asymptomatic’’ and ‘‘symptomatic’’ phenotypes were identified. Approximately 5–6% of asymptomatic children in childhood/later childhood and early adolescence became symptomatic later in time. Maternal common mental disorders were identified as important risk factor for unhealthy states. Conclusions Asthma manifestations are characterized by frequent movements, especially between childhood and adolescence. Our study, by simultaneously defining disease subtypes, and examining the transitions and their potential predictors, highlights the importance of longitudinal studies to advance the understanding of the effects of social, environmental and biological mechanisms underlying asthma trajectories over time. Keywords Latent transition analysis Longitudinal studies Childhood and adolescence Asthma symptoms
Introduction Electronic supplementary material The online version of this article (https://doi.org/10.1007/s00038-020-01435-x) contains supplementary material, which is available to authorized users.
Asthma is a chronic respiratory disease that most affects children and adolescents, being considered a major public health problem worldwide with a huge impact on the 3
& Leila Denise A. F. Amorim [email protected]
Center for Data and Knowledge Integration for Health (CIDACS), Fundac¸a˜o Oswaldo Cruz (FIOCRUZ), Salvador, Brazil
Ana Clara P. Campos [email protected] Agostino Strina [email protected] Maurı´cio L. Barreto [email protected] 1
Instituto de Sau´de Coletiva, Universidade Federal da Bahia, R. Bası´lio da Gama, s/n, Canela, Salvador, BA 40110-040, Brazil
2
Instituto de Matema´tica e Estatı´stica, Universidade Federal da Bahia, Campus Universita´rio de Ondina, Av. Adhemar de Barros, s/n, Salvador, BA 40170-110, Brazil
123
958
quality of life of patients and their families and significant economic costs (Reddel et al. 2015; GINA 2016). Individuals with asthma suffer not only from symptoms caused by the disease, b
Data Loading...