Unusual Thyroid Carcinoma Metastases: a Case Series and Literature Review
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Unusual Thyroid Carcinoma Metastases: a Case Series and Literature Review Eleonora Farina 1 & Fabio Monari 1 & Giovanni Tallini 2 & Andrea Repaci 3 & Renzo Mazzarotto 4 & Francesca Giunchi 5 & Riccardo Panzacchi 6 & Silvia Cammelli 1 & Gilbert D. A. Padula 7 & Francesco Deodato 8 & Renato Pasquali 3 & Stefano Fanti 9 & Michelangelo Fiorentino 5 & Alessio G. Morganti 1
Published online: 11 December 2015 # Springer Science+Business Media New York 2015
Abstract The most common sites of metastatic differentiated thyroid cancer are the neck lymph nodes, while distant metastases typically involve the lungs, the bones, and less frequently the brain. Uncommon metastatic sites include the liver, adrenal gland, kidney, pancreas, and skin. The epidemiological aspects of thyroid metastases in rare sites are largely unknown and their identification could have a significant impact on patients management. A mini-series of unusual metastatic sites of thyroid carcinoma is proposed as a contribution to current knowledge on anatomopathological characteristics and clinical outcome. Of the six cases that were assessed, the metastases were the following: skin metastases (2), skin and pancreas metastases (1), renal metastasis (1), adrenal metastasis (1), and liver metastasis (1). In our experience, metastases in rare sites do not always represent a negative prognostic factor for disease outcome. In fact they can occur as single distant lesion and if surgically resectable, their treatment can also lead to local disease remission.
Keywords Thyroid cancer . Cutaneous metastasis . Pancreatic metastasis . Renal metastasis . Adrenal metastasis . Liver metastasis
Introduction Thyroid carcinomas deriving from follicular epithelial cells are the most frequent endocrine tumors. They include follicular and papillary differentiated thyroid carcinoma (DTC), poorly differentiated carcinoma, and anaplastic carcinoma [1, 2]. The most common sites of metastases in these tumors are the neck lymph nodes, while distant metastases typically involve the lungs and bones and less frequently the brain. Uncommon metastatic sites include the liver, adrenal glands, kidney, pancreas, stomach, esophagus, distant skeletal muscle, penis, eye, choroid, and submandibular gland [1, 3–12]. Skin
Michelangelo Fiorentino and Alessio G. Morganti contributed equally to this work. * Fabio Monari [email protected] 1
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Pathology Unit of the BF. Addarii^ Institute of Oncology, Department of Oncology and Hematology, University of Bologna, S. Orsola-Malpighi Hospital, Via Massarenti 9, 40135 Bologna, Italy
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Radiation Oncology Center, Department of Experimental, Diagnostic and Specialty Medicine–DIMES, University of Bologna, S. Orsola-Malpighi Hospital, Via Massarenti 9, 40135 Bologna, Italy
Department of Pathology, University of Bologna, S. Orsola-Malpighi Hospital, Via Massarenti 9, 40135 Bologna, Italy
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Anatomic Pathology, Department of Experimental, Diagnostic and Specialty Medicine–DIMES, Bellaria Hospital, University of Bologna, Via Altura 3, 40139 Bologna, Italy
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