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Competition for publication in Diabetologia continues to grow, and less than 20% of papers are accepted. Of all the high-quality papers that appear in this month’s issue I want to draw your attention to five articles that I think are particularly interesting. The articles are summarised here. Our publisher, Springer, has kindly made the full text of each of these papers freely available. I hope you enjoy reading them! Sally M. Marshall, Editor
Next-generation epidemiology: the role of high-resolution molecular phenotyping in diabetes research
Intestinal microbial metabolites in human metabolism and type 2 diabetes
Paul W. Franks, Hugo Pomares-Millan
Hilde Herrema, Jan Hendrik Niess
Major advances in technologies that allow detailed molecular characterisations of many thousands of people have transformed epidemiology into a discipline at the forefront of biomedicine. In this issue, Franks and Pomares-Millan (https://doi.org/10.1007/s00125-020-05246-w) summarise recent advances in diabetes epidemiology that have been made possible through the availability of detailed genetic and molecular phenotype data in large cohorts, combined with the development and application of complex analytical processes. They explain that these studies have revealed novel molecular pathways that harbour promising targets for drug discovery, yielded evidence of gene– environment interactions that might facilitate targeted prevention of diabetes, and enabled the restratification of diabetes into aetiological subtypes that help elucidate the heterogeneous nature of type 2 diabetes. The figure from this review is available as a downloadable slide.
High-throughput technologies have helped to characterise the microbiome in individuals with the metabolic syndrome and type 2 diabetes. Emerging evidence suggests that it is not only the microorganisms and their structural components that contribute to the development of these conditions, but also the metabolites that they produce. In this issue, Herrema and Niess (https://doi.org/10.1007/s00125-020-05268-4) discuss recent advances in our understanding of how gut bacterial metabolites are sensed by individuals with the metabolic syndrome, potentially contributing to the development of type 2 diabetes. They explain how the gut microbiome, in response to dietary components, produces bacterial metabolites which influence processes implicated in the development of type 2 diabetes, including the intestinal immune system and the entero-endocrine system. Further studies on the impact of dietary components on gut bacterial metabolite production, as well as research into the receptors that recognise bacterial metabolites, promise to reveal new
Diabetologia
pathways that could be targeted for the treatment of the metabolic syndrome and type 2 diabetes. The figure from this review is available as a downloadable slide. Antibody response to multiple antigens of SARS-CoV-2 in patients with diabetes: an observational cohort study Vito Lampasona, Massimiliano Secchi, Marina Scavini, Elena Bazzigaluppi, Cris
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