Urinary incontinence and quality of life: a systematic review and meta-analysis
- PDF / 674,924 Bytes
- 11 Pages / 595.276 x 790.866 pts Page_size
- 20 Downloads / 176 Views
REVIEW ARTICLE
Urinary incontinence and quality of life: a systematic review and meta‑analysis Damiano Pizzol1 · Jacopo Demurtas2,3 · Stefano Celotto4 · Stefania Maggi5 · Lee Smith6 · Gabriele Angiolelli7 · Mike Trott6 · Lin Yang8,9 · Nicola Veronese7,10 Received: 11 June 2020 / Accepted: 19 August 2020 © The Author(s) 2020
Abstract Background Urinary incontinence (UI) and low quality of life (QoL) are two common conditions. Some recent literature proposed that these two entities can be associated. However, no attempt was made to collate this literature. Therefore, the aim of this study was to conduct a systematic review and meta-analysis of existing data to estimate the strength of the association between UI and QoL. Methods An electronic search of major databases up to 18th April 2020 was carried out. Meta-analysis of cross-sectional and case–control studies comparing mean values in QoL between patients with UI and controls was performed, reporting random-effects standardized mean differences (SMDs) ± 95% confidence intervals (CIs) as the effect size. Heterogeneity was assessed with the I2. Results Out of 8279 articles initially screened, 23 were finally included for a total of 24,983 participants, mainly women. The mean age was ≥ 50 years in 12/23 studies. UI was significantly associated with poor QoL as assessed by the short-form 36 (SF-36) total score (n = 6 studies; UI: 473 vs. 2971 controls; SMD = − 0.89; 95% CI − 1.3 to − 0.42; I2 = 93.5) and by the sub-scales of SF-36 and 5/8 of the domains included in the SF-36. Similar results were found using other QoL tools. The risk of bias of the studies included was generally high. Conclusions UI is associated with a poor QoL, with a strong level of certainty. This work, however, mainly based on cross-sectional and case–control studies, highlights the necessity of future longitudinal studies for better understanding the importance of UI on QoL. Keywords Quality of life · Urinary incontinence · Meta-analysis
Electronic supplementary material The online version of this article (https://doi.org/10.1007/s40520-020-01712-y) contains supplementary material, which is available to authorized users. * Nicola Veronese [email protected] 1
6
Faculty of Sport Sciences, University of Murcia, Murcia, Spain
7
Primary Care Department, Azienda Unità Locale Socio Sanitaria 3 “Serenissima”, Venice, Italy
8
Department of Cancer Epidemiology and Prevention Research, Cancer Control Alberta, Alberta Health Services, Calgary, Canada
Departments of Oncology and Community Health Sciences, University of Calgary, Calgary, Canada
Italian Agency for Development Cooperation, Khartoum, Sudan
2
Clinical and Experimental Medicine PhD Program, University of Modena and Reggio Emilia, Modena, Italy
3
Primary Care Department, USL Toscana Sud Est-Grosseto, Grosseto, Italy
9
4
Primary Care Department, Azienda Sanitaria Universitaria Friuli Centrale, Udine, Italy
10
5
National Research Council, Neuroscience Institute, Aging Branch, Padua, Italy
Geriatr
Data Loading...
