Urinary tract infections in neonates with jaundice in their first two weeks of life
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Urinary tract infections in neonates with jaundice in their first two weeks of life Mehmet Mutlu, Yasemin Çayır, Yakup Aslan Erzurum, Turkey
Conclusion: UTI should be investigated in neonates with hyperbilirubinemia of unknown etiology in the first two weeks of life.
Methods
Methods: The study was conducted prospectively. The subjects were neonates aged 4-14 days with hyperbilirubinemia which could not be detected by routine tests and was sufficiently severe to necessitate phototherapy.
World J Pediatr June 2013; Online First Key words: hyperbilirubinemia; neonate; urinary tract infection
Introduction
H
yperbilirubinemia is a frequently seen condition in the newborn period. While bilirubin levels remain within physiological limits in some newborns, they may rise to pathological levels necessitating treatment in others. While a specific
Author Affiliations: Department of Neonatology (Mutlu M) and Department of Family Physician (Çayır Y), Erzurum Regional Training and Research Hospital, Neonatal Intensive Care Unit, Erzurum, Turkey; Department of Neonatology, Karadeniz Technical University, Neonatal Intensive Care Unit, Trabzon, Turkey (Aslan Y) Corresponding Author: Mehmet Mutlu, Department of Neonatology, Erzurum Regional Training and Research Hospital, Neonatal Intensive Care Unit, Erzurum, Turkey (Tel: 0442 2326166; Fax: 0442 2325090; Email: [email protected]) doi: 10.1007/s12519-013-0433-1 ©Children's Hospital, Zhejiang University School of Medicine, China and Springer-Verlag Berlin Heidelberg 2013. All rights reserved.
World J Pediatr, Online First, October 2013 . www.wjpch.com
Subjects This descriptive study was performed in the Newborn Intensive Care Unit at the Erzurum Regional Training and Research Hospital in Turkey between October 1, 2010 and July 1, 2011. Subjects enrolled in the study were neonates at age of 4-14 days and had a gestational age greater than 35 weeks, with jaundice above the phototherapy limits set by the American Academy of Pediatrics.[5] They had no signs of systemic infection such as fever or hypothermia, tachypnea, tachycardia, an abnormal white cell count and increased immature cells, nor prolonged rupture of membranes, no history of maternal infection and no identified causes such as isoimmunization, sequestration or polycythemia that might account for the jaundice. Gestational and postnatal age, birth weight, postnatal weight, type of delivery, sex, feeding type, bilirubin level at presentation, phototherapy duration and rebound bilirubin level were recorded for all the neonates enrolled. Baby's blood group, mother's blood group, direct Coombs test, hemogram, peripheral blood smear, reticulocyte count, total and direct bilirubin level and full urine analysis, including urine microscopy, were determined or performed for all cases. Thyroid function tests were also performed. Urine sample was obtained using the catheterization technique from 1
Original article
Results: The study was performed in 104 neonates, of whom 18% (n=19) had UTI. The most frequently identi
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