Urinary Tract

The basic anatomy and physiology of the urinary tract, the validity of animal models and other methodological considerations as well as a range of potential therapeutic targets are comprehensively reviewed by leading international experts, making this a u

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Volume 202

Editor-in-Chief Franz B. Hofmann

Editorial Board Joseph A. Beavo Detlev Ganten Jan-Anders Karlsson Martin C. Michel Clive P. Page Walter Rosenthal

For further volumes: http://www.springer.com/series/164

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Karl-Erik Andersson

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Martin C. Michel

Editors

Urinary Tract

Editors Dr. Karl-Erik Andersson Wake Forest University Medical Center Blvd. 27157-1088 Winston-Salem North Carolina USA [email protected]

Prof. Dr. Martin C. Michel University of Amsterdam Academic Medical Center Dept. Pharmacology & Pharmacotherapy Meibergdreef 15 1105 AZ Amsterdam Netherlands [email protected]

ISSN 0171-2004 e-ISSN 1865-0325 ISBN 978-3-642-16498-9 e-ISBN 978-3-642-16499-6 DOI 10.1007/978-3-642-16499-6 Springer Heidelberg Dordrecht London New York Library of Congress Control Number: 2011921350 # Springer-Verlag Berlin Heidelberg 2011 This work is subject to copyright. All rights are reserved, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilm or in any other way, and storage in data banks. Duplication of this publication or parts thereof is permitted only under the provisions of the German Copyright Law of September 9, 1965, in its current version, and permission for use must always be obtained from Springer. Violations are liable to prosecution under the German Copyright Law. The use of general descriptive names, registered names, trademarks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. Cover design: deblik, Berlin Printed on acid-free paper Springer is part of Springer Science+Business Media (www.springer.com)

This book is dedicated to the memory of the late Prof. Alison Brading who passed away while this book was being produced.

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Preface

Functional disorders of the urinary tract are common and in many cases have major adverse effects on the quality of life of the afflicted patients. These include disorders of the ureters, the bladder, the urethra, the prostate and the pelvic floor. For a long time, only surgical approaches and conservative treatment could be offered for such disorders. The last two decades have seen an amazing proliferation of knowledge in the field of anatomy, physiology and pharmacology of the urinary tract. Several major new treatments have emerged from such research and are benefitting millions of patients. However, therapeutic needs remain and only a profound knowledge on the underlying tissue, cell and molecular processes is likely to provide novel treatments addressing such needs. Therefore, we are very happy that internationally leading experts have contributed to the writing of this book and we thank all of them for their efforts. Their combined insight provides a comprehensive overview of the state of knowledge regarding the pharmacology of the urinary tract. Therefore, we tru