Use and Deprescribing of Potentially Inappropriate Medications in Frail Nursing Home Residents
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ORIGINAL RESEARCH ARTICLE
Use and Deprescribing of Potentially Inappropriate Medications in Frail Nursing Home Residents Anne Fournier1,2 · Pauline Anrys1 · Jean‑Baptiste Beuscart3 · Olivia Dalleur1,2 · Séverine Henrard1,4 · Veerle Foulon5 · Anne Spinewine1,6 Accepted: 27 September 2020 © Springer Nature Switzerland AG 2020
Abstract Background The STOPPFrail criteria were developed to assist physicians in deprescribing medications among frail patients approaching end of life. We aimed to measure the prevalence of potentially inappropriate medications (PIMs) and to describe changes over time, using STOPPFrail, in frail nursing home residents (NHRs) with limited life expectancy included in a medication review trial. Methods We conducted a post-hoc analysis of the COME-ON study, a cluster-controlled trial that evaluated the effect of a complex intervention on appropriateness of prescribing in Belgian nursing homes. We identified NHRs eligible for the application of STOPPFrail based on functional status, comorbidities, level of care and survival. PIM use was measured at baseline and at 8 months. Changes over time were compared in the control group (CG) and intervention group (IG). Results At baseline, 308 NHRs met the STOPPFrail eligibility criteria, of whom 196 (64.1%) had one or more PIM. At 8 months, among the 218 NHRs who were alive, there was an absolute reduction in the prevalence of PIMs of 9.1% in the CG (p
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