Use of antipyretics for preventing febrile seizure recurrence in children: a systematic review and meta-analysis
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REVIEW
Use of antipyretics for preventing febrile seizure recurrence in children: a systematic review and meta-analysis Risa Hashimoto 1,2 Masaya Kubota 4
&
Maiko Suto 2 & Mariko Tsuji 2 & Hatoko Sasaki 3 & Kenji Takehara 2 & Akira Ishiguro 1 &
Received: 1 February 2020 / Revised: 8 October 2020 / Accepted: 13 October 2020 # Springer-Verlag GmbH Germany, part of Springer Nature 2020
Abstract The efficacy of antipyretics for preventing febrile seizure recurrence has been reported by a recent study, and the results might overturn previous evidence. We systematically reviewed the efficacy of antipyretics in the prevention of febrile seizure recurrence in children focused on the timing of its administration. We searched the Medline, Embase, and Cochrane Central Register of Controlled Trials databases for randomized and quasi-randomized trials and prospective non-randomized studies of aged up to 60 months, diagnosed with febrile seizure, who were treated with antipyretics. Data were extracted from eight studies. Only one study reported that antipyretics prevented the recurrence of febrile seizures within the same fever episode (9.1% in the acetaminophen group vs. 23.5% in the control group, p < 0.01). Four studies found no evidence for the efficacy of antipyretics in preventing febrile seizure recurrence in distant fever episodes (odds ratio, 0.92; 95% confidence interval, 0.57–1.48, for two randomized controlled studies). Conclusion: This review provides very limited support for the use of antipyretics in preventing febrile seizure recurrence within the same fever episode and no evidence for its use in distant fever episodes. New studies are required to evaluate this topic further and determine whether the effectiveness of antipyretics is based on intervention timing. What is Known: • Reviews of prophylactic drug management among febrile seizure children found that antipyretics had no significant benefits. • Recent data suggest that antipyretics are effective in preventing febrile seizures. What is New: • Weak evidence suggests a possible role in preventing febrile seizure recurrence within the same fever episode. • There is clearly no role for antipyretic prophylaxis in preventing febrile seizures during distant fever episodes.
Keywords Antipyretics . Antiseizure drugs . Febrile seizure . Prevention . Recurrence . Systematic review Communicated by Gregorio Paolo Milani Supplementary Information The online version of this article (https:// doi.org/10.1007/s00431-020-03845-8) contains supplementary material, which is available to authorized users. * Risa Hashimoto [email protected]; [email protected] Maiko Suto [email protected]
Masaya Kubota [email protected] 1
Mariko Tsuji [email protected]
Center for Postgraduate Education and Training, National Center for Child Health and Development, 2-10-1 Okura, Setagaya-ku, Tokyo 157-8535, Japan
2
Hatoko Sasaki [email protected]
Department of Health Policy, National Center for Child Health and Development, Tokyo, Japan
3
Medical Supp
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